Substituent effects on the in situ activation of the double activated cross-linking reaction.

Fumi Nagatsugi, Sayaka Mori, Md Monsur Ali, Yuki Ogata, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported that the oligonucleotides (ODN) containing 2-amino-6-(1-ethylsulfinyl)vinyl purine derivatives (2) exhibit selective and efficient cross-linking to a cytidine at the target site under neutral conditions. In addition, bis-alkylsulfinyl derivative (3b) as the stable precursor of 2 showed the moderate reactivity. In this study, we have searched other bis-alkylsulfinyl precursors to achieve higher cross-linking ability, and found that acetamidoethyl and hydroxyethyl derivatives showed highly efficient and selective reactivity.

Original languageEnglish
Pages (from-to)175-176
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
DOIs
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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