From p-t-butylcalixarene bis(diethylphosphate) ester(1), monodehydroxymonoamino-p-t-butylcalixarene (3) and diamino-p-t-butyl-calixarene (4) were synthesized in liquid ammonia-co-solvent in the presence of KNH2. This is the first successful example for the substitution of the OH group with the NH2 group.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry