Substitution of oh with nh2 calix[4]arenes: An approach to the synthesis of aminocalixarenes

Fumio Ohseto, Hiroto Murakami, Koji Araki, Seiji Shinkai

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Abstract

From p-t-butylcalix[4]arene bis(diethylphosphate) ester(1), monodehydroxymonoamino-p-t-butylcalix[4]arene (3) and diamino-p-t-butyl-calix[4]arene (4) were synthesized in liquid ammonia-co-solvent in the presence of KNH2. This is the first successful example for the substitution of the OH group with the NH2 group.

Original languageEnglish
Pages (from-to)1217-1220
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number9
DOIs
Publication statusPublished - Feb 25 1992

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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