Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese

Keiichiro Mine, Kanako Hirakawa, Shiori Kondo, Masae Minami, Akira Okada, Nobutaka Tsutsu, Yasushi Yokogawa, Yumi Hibio, Fumiko Kojima, Shuji Fujimoto, Hironori Kurisaki, Keizo Anzai, Yasunobu Yoshikai, Seiho Nagafuchi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. Research Design and Methods: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese. Results: T1D patients had elevated IgE (median, 56.7. U/ml; p <. 0.0001) compared with T2D patients (22.5. U/ml) and controls (43.3. U/ml). Contrary to our expectations, there was no correlation between TYK2 promoter variant and IgE levels. We found that T1D could be subtyped as four groups based on anti-GAD Ab and IgE profile: Subtype 1, anti-GAD Ab positive and non-elevated IgE (47.0%); Subtype 2, anti-GAD Ab negative and non-elevated IgE (35.1%); Subtype 3, anti-GAD Ab positive and elevated IgE (10.9%); and Subtype 4, anti-GAD Ab negative and elevated IgE (7.0%). In Subtype 2, a significantly higher incidence was observed in T1D cases carrying the TYK2 promoter variant (OR, 2.60; 95%CI, 1.03-6.97; p = 0.032), and also showing a flu-like syndrome at diabetes onset (OR, 2.34; 95%CI, 1.27-4.35; p = 0.003). Interpretation: Anti-GAD Ab and IgE profiling helps classifying T1D into four groups that recognize variable pathogenic bases of T1D.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalEBioMedicine
Volume23
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

TYK2 Kinase
Medical problems
Type 1 Diabetes Mellitus
Immunoglobulin E
Antibodies
Th1-Th2 Balance
anti-IgE antibodies
Th2 Cells
Th1 Cells
Autoimmunity
Interferons
Antiviral Agents
Viruses
Research Design
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese. / Mine, Keiichiro; Hirakawa, Kanako; Kondo, Shiori; Minami, Masae; Okada, Akira; Tsutsu, Nobutaka; Yokogawa, Yasushi; Hibio, Yumi; Kojima, Fumiko; Fujimoto, Shuji; Kurisaki, Hironori; Anzai, Keizo; Yoshikai, Yasunobu; Nagafuchi, Seiho.

In: EBioMedicine, Vol. 23, 2017, p. 46-51.

Research output: Contribution to journalArticle

Mine, K, Hirakawa, K, Kondo, S, Minami, M, Okada, A, Tsutsu, N, Yokogawa, Y, Hibio, Y, Kojima, F, Fujimoto, S, Kurisaki, H, Anzai, K, Yoshikai, Y & Nagafuchi, S 2017, 'Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese', EBioMedicine, vol. 23, pp. 46-51. https://doi.org/10.1016/j.ebiom.2017.08.012
Mine, Keiichiro ; Hirakawa, Kanako ; Kondo, Shiori ; Minami, Masae ; Okada, Akira ; Tsutsu, Nobutaka ; Yokogawa, Yasushi ; Hibio, Yumi ; Kojima, Fumiko ; Fujimoto, Shuji ; Kurisaki, Hironori ; Anzai, Keizo ; Yoshikai, Yasunobu ; Nagafuchi, Seiho. / Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese. In: EBioMedicine. 2017 ; Vol. 23. pp. 46-51.
@article{64828088c04e424e93025c591e5de15d,
title = "Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese",
abstract = "Objective: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. Research Design and Methods: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese. Results: T1D patients had elevated IgE (median, 56.7. U/ml; p <. 0.0001) compared with T2D patients (22.5. U/ml) and controls (43.3. U/ml). Contrary to our expectations, there was no correlation between TYK2 promoter variant and IgE levels. We found that T1D could be subtyped as four groups based on anti-GAD Ab and IgE profile: Subtype 1, anti-GAD Ab positive and non-elevated IgE (47.0{\%}); Subtype 2, anti-GAD Ab negative and non-elevated IgE (35.1{\%}); Subtype 3, anti-GAD Ab positive and elevated IgE (10.9{\%}); and Subtype 4, anti-GAD Ab negative and elevated IgE (7.0{\%}). In Subtype 2, a significantly higher incidence was observed in T1D cases carrying the TYK2 promoter variant (OR, 2.60; 95{\%}CI, 1.03-6.97; p = 0.032), and also showing a flu-like syndrome at diabetes onset (OR, 2.34; 95{\%}CI, 1.27-4.35; p = 0.003). Interpretation: Anti-GAD Ab and IgE profiling helps classifying T1D into four groups that recognize variable pathogenic bases of T1D.",
author = "Keiichiro Mine and Kanako Hirakawa and Shiori Kondo and Masae Minami and Akira Okada and Nobutaka Tsutsu and Yasushi Yokogawa and Yumi Hibio and Fumiko Kojima and Shuji Fujimoto and Hironori Kurisaki and Keizo Anzai and Yasunobu Yoshikai and Seiho Nagafuchi",
year = "2017",
doi = "10.1016/j.ebiom.2017.08.012",
language = "English",
volume = "23",
pages = "46--51",
journal = "EBioMedicine",
issn = "2352-3964",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese

AU - Mine, Keiichiro

AU - Hirakawa, Kanako

AU - Kondo, Shiori

AU - Minami, Masae

AU - Okada, Akira

AU - Tsutsu, Nobutaka

AU - Yokogawa, Yasushi

AU - Hibio, Yumi

AU - Kojima, Fumiko

AU - Fujimoto, Shuji

AU - Kurisaki, Hironori

AU - Anzai, Keizo

AU - Yoshikai, Yasunobu

AU - Nagafuchi, Seiho

PY - 2017

Y1 - 2017

N2 - Objective: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. Research Design and Methods: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese. Results: T1D patients had elevated IgE (median, 56.7. U/ml; p <. 0.0001) compared with T2D patients (22.5. U/ml) and controls (43.3. U/ml). Contrary to our expectations, there was no correlation between TYK2 promoter variant and IgE levels. We found that T1D could be subtyped as four groups based on anti-GAD Ab and IgE profile: Subtype 1, anti-GAD Ab positive and non-elevated IgE (47.0%); Subtype 2, anti-GAD Ab negative and non-elevated IgE (35.1%); Subtype 3, anti-GAD Ab positive and elevated IgE (10.9%); and Subtype 4, anti-GAD Ab negative and elevated IgE (7.0%). In Subtype 2, a significantly higher incidence was observed in T1D cases carrying the TYK2 promoter variant (OR, 2.60; 95%CI, 1.03-6.97; p = 0.032), and also showing a flu-like syndrome at diabetes onset (OR, 2.34; 95%CI, 1.27-4.35; p = 0.003). Interpretation: Anti-GAD Ab and IgE profiling helps classifying T1D into four groups that recognize variable pathogenic bases of T1D.

AB - Objective: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. Research Design and Methods: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese. Results: T1D patients had elevated IgE (median, 56.7. U/ml; p <. 0.0001) compared with T2D patients (22.5. U/ml) and controls (43.3. U/ml). Contrary to our expectations, there was no correlation between TYK2 promoter variant and IgE levels. We found that T1D could be subtyped as four groups based on anti-GAD Ab and IgE profile: Subtype 1, anti-GAD Ab positive and non-elevated IgE (47.0%); Subtype 2, anti-GAD Ab negative and non-elevated IgE (35.1%); Subtype 3, anti-GAD Ab positive and elevated IgE (10.9%); and Subtype 4, anti-GAD Ab negative and elevated IgE (7.0%). In Subtype 2, a significantly higher incidence was observed in T1D cases carrying the TYK2 promoter variant (OR, 2.60; 95%CI, 1.03-6.97; p = 0.032), and also showing a flu-like syndrome at diabetes onset (OR, 2.34; 95%CI, 1.27-4.35; p = 0.003). Interpretation: Anti-GAD Ab and IgE profiling helps classifying T1D into four groups that recognize variable pathogenic bases of T1D.

UR - http://www.scopus.com/inward/record.url?scp=85027465372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027465372&partnerID=8YFLogxK

U2 - 10.1016/j.ebiom.2017.08.012

DO - 10.1016/j.ebiom.2017.08.012

M3 - Article

C2 - 28826655

AN - SCOPUS:85027465372

VL - 23

SP - 46

EP - 51

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

ER -