Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia

Yasuhiro Nakashima, Yasunobu Abe, Yoshimichi Tachikawa, Rie Ohtsuka, Eriko Sada, Koichiro Muta, Ryoichi Takayanagi

Research output: Contribution to journalArticle

Abstract

A 55-year-old man with acute promyelocytic leukemia in the first relapse was treated with arsenic trioxide as salvage therapy. After obtaining molecular remission, he underwent autologous peripheral blood stem cell transplantation (PBSCT) with busulfan and melphalan conditioning. The transplant dose of CD 34-positive cells was sufficient, and engraftment was prompt. Platelet count increased to 320 x 10(9)/1 on day 21; however, it rapidly decreased to 27 x 10(9)/l on day 37. Despite treatment with corticosteroid, the platelet count decreased to 6 x 10(9)/l on day 55. About one month after cyclosporine administration, thrombocytopenia gradually improved. This clinical course suggests immune-mediated thrombocytopenia following autologous PBSCT.

Original languageEnglish
Pages (from-to)1567-1569
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume48
Issue number12
Publication statusPublished - Dec 2007

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Peripheral Blood Stem Cell Transplantation
Salvage Therapy
Acute Promyelocytic Leukemia
Hematopoietic Stem Cell Transplantation
Platelet Count
Thrombocytopenia
Cyclosporine
Busulfan
Melphalan
Idiopathic Thrombocytopenic Purpura
Adrenal Cortex Hormones
Transplants
Recurrence
Therapeutics
arsenic trioxide

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia. / Nakashima, Yasuhiro; Abe, Yasunobu; Tachikawa, Yoshimichi; Ohtsuka, Rie; Sada, Eriko; Muta, Koichiro; Takayanagi, Ryoichi.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 48, No. 12, 12.2007, p. 1567-1569.

Research output: Contribution to journalArticle

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