Abstract
A 55-year-old man with acute promyelocytic leukemia in the first relapse was treated with arsenic trioxide as salvage therapy. After obtaining molecular remission, he underwent autologous peripheral blood stem cell transplantation (PBSCT) with busulfan and melphalan conditioning. The transplant dose of CD 34-positive cells was sufficient, and engraftment was prompt. Platelet count increased to 320 x 10(9)/1 on day 21; however, it rapidly decreased to 27 x 10(9)/l on day 37. Despite treatment with corticosteroid, the platelet count decreased to 6 x 10(9)/l on day 55. About one month after cyclosporine administration, thrombocytopenia gradually improved. This clinical course suggests immune-mediated thrombocytopenia following autologous PBSCT.
| Original language | English |
|---|---|
| Pages (from-to) | 1567-1569 |
| Number of pages | 3 |
| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| Volume | 48 |
| Issue number | 12 |
| Publication status | Published - Dec 2007 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia. / Nakashima, Yasuhiro; Abe, Yasunobu; Tachikawa, Yoshimichi; Ohtsuka, Rie; Sada, Eriko; Muta, Koichiro; Takayanagi, Ryoichi.
In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 48, No. 12, 12.2007, p. 1567-1569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia
AU - Nakashima, Yasuhiro
AU - Abe, Yasunobu
AU - Tachikawa, Yoshimichi
AU - Ohtsuka, Rie
AU - Sada, Eriko
AU - Muta, Koichiro
AU - Takayanagi, Ryoichi
PY - 2007/12
Y1 - 2007/12
N2 - A 55-year-old man with acute promyelocytic leukemia in the first relapse was treated with arsenic trioxide as salvage therapy. After obtaining molecular remission, he underwent autologous peripheral blood stem cell transplantation (PBSCT) with busulfan and melphalan conditioning. The transplant dose of CD 34-positive cells was sufficient, and engraftment was prompt. Platelet count increased to 320 x 10(9)/1 on day 21; however, it rapidly decreased to 27 x 10(9)/l on day 37. Despite treatment with corticosteroid, the platelet count decreased to 6 x 10(9)/l on day 55. About one month after cyclosporine administration, thrombocytopenia gradually improved. This clinical course suggests immune-mediated thrombocytopenia following autologous PBSCT.
AB - A 55-year-old man with acute promyelocytic leukemia in the first relapse was treated with arsenic trioxide as salvage therapy. After obtaining molecular remission, he underwent autologous peripheral blood stem cell transplantation (PBSCT) with busulfan and melphalan conditioning. The transplant dose of CD 34-positive cells was sufficient, and engraftment was prompt. Platelet count increased to 320 x 10(9)/1 on day 21; however, it rapidly decreased to 27 x 10(9)/l on day 37. Despite treatment with corticosteroid, the platelet count decreased to 6 x 10(9)/l on day 55. About one month after cyclosporine administration, thrombocytopenia gradually improved. This clinical course suggests immune-mediated thrombocytopenia following autologous PBSCT.
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UR - http://www.scopus.com/inward/citedby.url?scp=40349093280&partnerID=8YFLogxK
M3 - Article
C2 - 18203519
AN - SCOPUS:40349093280
VL - 48
SP - 1567
EP - 1569
JO - [Rinsho ketsueki] The Japanese journal of clinical hematology
JF - [Rinsho ketsueki] The Japanese journal of clinical hematology
SN - 0485-1439
IS - 12
ER -