Successful endoscopic treatment of hepatoduodenal fistula formed during sorafenib treatment for hepatocellular carcinoma with duodenal invasion

Koji Imoto, Motoyuki Kohjima, Tomoyuki Kurashige, Taiji Mutsuki, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masaki Kato, Yoshihiro Ogawa

Research output: Contribution to journalArticle

Abstract

Here, we have reported a case of hepatocellular carcinoma (HCC) with a duodenal fistula that was treated with endoscopic procedure in a 79-year-old female patient who was admitted to our hospital with melena. She was diagnosed with recurrent HCC with duodenal bulb invasion and hemorrhage. After 2 months of sorafenib treatment, an improvement in HCC was noted, while a hepatoduodenal fistula was detected at the invasion site. Hepatoduodenal fistula occurring in duodenal invasion of HCC often produces intractable infection and worsens prognosis. We successfully closed the fistula using argon plasma coagulation (APC), following endoscopic injection with fibrin glue and polyglycolic acid sheet coverage. Recent developments in chemotherapy for advanced HCC may provide similar cases with hepatoduodenal fistula occurring in duodenal invasion of HCC and endoscopic treatment could be one of the therapeutic options in such cases.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalActa Hepatologica Japonica
Volume60
Issue number3
DOIs
Publication statusPublished - Jan 1 2019

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Fistula
Hepatocellular Carcinoma
Therapeutics
Argon Plasma Coagulation
Polyglycolic Acid
Melena
Fibrin Tissue Adhesive
sorafenib
Hemorrhage
Drug Therapy
Injections
Infection

All Science Journal Classification (ASJC) codes

  • Hepatology

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Successful endoscopic treatment of hepatoduodenal fistula formed during sorafenib treatment for hepatocellular carcinoma with duodenal invasion. / Imoto, Koji; Kohjima, Motoyuki; Kurashige, Tomoyuki; Mutsuki, Taiji; Tashiro, Shigeki; Suzuki, Hideo; Kuwano, Akifumi; Kato, Masaki; Ogawa, Yoshihiro.

In: Acta Hepatologica Japonica, Vol. 60, No. 3, 01.01.2019, p. 91-98.

Research output: Contribution to journalArticle

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