Successful hyperbaric oxygen therapy for laryngeal radionecrosis after chemoradiotherapy for mesopharyngeal cancer: Case report and literature review

Madoka Abe, Kotaro Terashima, Iwao Hara, Yoshiyuki Shioyama, Mioko Matsuo, Satoru Uehara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Laryngeal radionecrosis is one of the most troublesome late complications of radiotherapy, because it is frequently resistant to treatment and laryngectomy is required in the worst case. Here, we report a case of laryngeal radionecrosis, successfully treated by use of hyperbaric oxygen (HBO) therapy, in which laryngectomy was avoided. A 67-year-old male received radical chemoradiotherapy (CRT) for mesopharyngeal cancer, which included radiotherapy with a total dose of 71.4 Gy/38 Fr and chemotherapy with CDDP + S-1. He developed dyspnea and throat pain 9 months after completion of CRT. Laryngoscopy revealed vocal cord impairment because of severe laryngeal edema. He was diagnosed as having laryngeal radionecrosis and initially received conservative therapy combined with antibiotics, steroids, and prostaglandins. Because his dyspnea was persistent despite this treatment, HBO therapy was administered 20 times, and resulted in complete remission of the dyspnea. HBO therapy, therefore, is regarded as an effective conservative therapeutic option for laryngeal radionecrosis.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalJapanese Journal of Radiology
Volume30
Issue number4
DOIs
Publication statusPublished - May 1 2012

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Hyperbaric Oxygenation
Chemoradiotherapy
Dyspnea
Laryngectomy
Radiotherapy
Laryngeal Edema
Neoplasms
Laryngoscopy
Vocal Cords
Pharynx
Prostaglandins
Therapeutics
Steroids
Anti-Bacterial Agents
Drug Therapy
Pain

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Successful hyperbaric oxygen therapy for laryngeal radionecrosis after chemoradiotherapy for mesopharyngeal cancer : Case report and literature review. / Abe, Madoka; Terashima, Kotaro; Hara, Iwao; Shioyama, Yoshiyuki; Matsuo, Mioko; Uehara, Satoru.

In: Japanese Journal of Radiology, Vol. 30, No. 4, 01.05.2012, p. 340-344.

Research output: Contribution to journalArticle

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