Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo

Yasuki Nagai, Yuichi Hatsukawa, Tadahiro Kin, Kazuyuki Hashimoto, Shoji Motoishi, Chikara Konno, Kentaro Ochiai, Kosuke Takakura, Yuichi Sato, Yukimasa Kawauchi, Norihito Sato, Akio Ohta, Hisamichi Yamabayashi, Masakazu Tanase, Saburo Fujisaki, Tomoyuki Teranaka, Nobuhiro Takeuchi, Takashi Igarashi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have for the first time succeeded in separating 99mTc from a MoO3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99mTc-methylene diphosphonate (99mTc-MDP). 99Mo, the mother nuclide of 99mTc, was produced by the 100Mo(n; 2n)99Mo reaction using about 14MeV neutrons provided by the 3H(d; n) 4He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99mTc was separated from 99Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by γ-spectroscopy. The labeling efficiency of 99mTc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99Mo. Consequently, a 99mTc radiopharmaceutical preparation formed by using the mentioned 99Mo can be a promising substitute for the fission product 99Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99Mo in Japan can be partially mitigated.

Original languageEnglish
Article number083201
Journaljournal of the physical society of japan
Volume80
Issue number8
DOIs
Publication statusPublished - Aug 1 2011
Externally publishedYes

Fingerprint

fission products
methylene
marking
Japan
thin layer chromatography
neutrons
nuclides
nuclear energy
sublimation
radioactive isotopes
uranium
purity
accelerators
fusion
reactors
substitutes
impurities
requirements
preparation
spectroscopy

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo. / Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi; Kawauchi, Yukimasa; Sato, Norihito; Ohta, Akio; Yamabayashi, Hisamichi; Tanase, Masakazu; Fujisaki, Saburo; Teranaka, Tomoyuki; Takeuchi, Nobuhiro; Igarashi, Takashi.

In: journal of the physical society of japan, Vol. 80, No. 8, 083201, 01.08.2011.

Research output: Contribution to journalArticle

Nagai, Y, Hatsukawa, Y, Kin, T, Hashimoto, K, Motoishi, S, Konno, C, Ochiai, K, Takakura, K, Sato, Y, Kawauchi, Y, Sato, N, Ohta, A, Yamabayashi, H, Tanase, M, Fujisaki, S, Teranaka, T, Takeuchi, N & Igarashi, T 2011, 'Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo', journal of the physical society of japan, vol. 80, no. 8, 083201. https://doi.org/10.1143/JPSJ.80.083201
Nagai, Yasuki ; Hatsukawa, Yuichi ; Kin, Tadahiro ; Hashimoto, Kazuyuki ; Motoishi, Shoji ; Konno, Chikara ; Ochiai, Kentaro ; Takakura, Kosuke ; Sato, Yuichi ; Kawauchi, Yukimasa ; Sato, Norihito ; Ohta, Akio ; Yamabayashi, Hisamichi ; Tanase, Masakazu ; Fujisaki, Saburo ; Teranaka, Tomoyuki ; Takeuchi, Nobuhiro ; Igarashi, Takashi. / Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo. In: journal of the physical society of japan. 2011 ; Vol. 80, No. 8.
@article{0f256f7f2d2b41469721d510fe3cb207,
title = "Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo",
abstract = "We have for the first time succeeded in separating 99mTc from a MoO3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99mTc-methylene diphosphonate (99mTc-MDP). 99Mo, the mother nuclide of 99mTc, was produced by the 100Mo(n; 2n)99Mo reaction using about 14MeV neutrons provided by the 3H(d; n) 4He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99mTc was separated from 99Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99{\%} by γ-spectroscopy. The labeling efficiency of 99mTc-MDP was shown to be higher than 99{\%} by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99Mo. Consequently, a 99mTc radiopharmaceutical preparation formed by using the mentioned 99Mo can be a promising substitute for the fission product 99Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99Mo in Japan can be partially mitigated.",
author = "Yasuki Nagai and Yuichi Hatsukawa and Tadahiro Kin and Kazuyuki Hashimoto and Shoji Motoishi and Chikara Konno and Kentaro Ochiai and Kosuke Takakura and Yuichi Sato and Yukimasa Kawauchi and Norihito Sato and Akio Ohta and Hisamichi Yamabayashi and Masakazu Tanase and Saburo Fujisaki and Tomoyuki Teranaka and Nobuhiro Takeuchi and Takashi Igarashi",
year = "2011",
month = "8",
day = "1",
doi = "10.1143/JPSJ.80.083201",
language = "English",
volume = "80",
journal = "Journal of the Physical Society of Japan",
issn = "0031-9015",
publisher = "Physical Society of Japan",
number = "8",

}

TY - JOUR

T1 - Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo

AU - Nagai, Yasuki

AU - Hatsukawa, Yuichi

AU - Kin, Tadahiro

AU - Hashimoto, Kazuyuki

AU - Motoishi, Shoji

AU - Konno, Chikara

AU - Ochiai, Kentaro

AU - Takakura, Kosuke

AU - Sato, Yuichi

AU - Kawauchi, Yukimasa

AU - Sato, Norihito

AU - Ohta, Akio

AU - Yamabayashi, Hisamichi

AU - Tanase, Masakazu

AU - Fujisaki, Saburo

AU - Teranaka, Tomoyuki

AU - Takeuchi, Nobuhiro

AU - Igarashi, Takashi

PY - 2011/8/1

Y1 - 2011/8/1

N2 - We have for the first time succeeded in separating 99mTc from a MoO3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99mTc-methylene diphosphonate (99mTc-MDP). 99Mo, the mother nuclide of 99mTc, was produced by the 100Mo(n; 2n)99Mo reaction using about 14MeV neutrons provided by the 3H(d; n) 4He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99mTc was separated from 99Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by γ-spectroscopy. The labeling efficiency of 99mTc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99Mo. Consequently, a 99mTc radiopharmaceutical preparation formed by using the mentioned 99Mo can be a promising substitute for the fission product 99Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99Mo in Japan can be partially mitigated.

AB - We have for the first time succeeded in separating 99mTc from a MoO3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99mTc-methylene diphosphonate (99mTc-MDP). 99Mo, the mother nuclide of 99mTc, was produced by the 100Mo(n; 2n)99Mo reaction using about 14MeV neutrons provided by the 3H(d; n) 4He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99mTc was separated from 99Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by γ-spectroscopy. The labeling efficiency of 99mTc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99Mo. Consequently, a 99mTc radiopharmaceutical preparation formed by using the mentioned 99Mo can be a promising substitute for the fission product 99Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99Mo in Japan can be partially mitigated.

UR - http://www.scopus.com/inward/record.url?scp=80051594081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051594081&partnerID=8YFLogxK

U2 - 10.1143/JPSJ.80.083201

DO - 10.1143/JPSJ.80.083201

M3 - Article

VL - 80

JO - Journal of the Physical Society of Japan

JF - Journal of the Physical Society of Japan

SN - 0031-9015

IS - 8

M1 - 083201

ER -