Successful liver transplantation for transient abnormal myelopoiesis-associated liver failure

Research output: Contribution to journalArticle

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Abstract

Infants with Down syndrome (DS) are at risk of developing a transient abnormal myelopoiesis (TAM). TAM occasionally involves liver fibrosis, which can be fatal. The management of liver disease in TAM has not yet been established and is mainly supportive. We report an infant with DS and TAM who developed end-stage liver failure. Liver dysfunction progressed even after blast cells disappeared from the circulation. He underwent a living-donor liver transplantation at 56 days of life without surgical complications. The explanted liver showed atrophy and severe fibrosis without leukemic cell infiltration. The posttransplant course was favorable with no hematological abnormality. He is doing well 8 months after transplantation. To the best of our knowledge, this report is the first showing that liver transplantation might be a treatment option for TAM-related liver failure.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalNeonatology
Volume112
Issue number2
DOIs
Publication statusPublished - Aug 1 2017

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Liver Failure
Liver Transplantation
Down Syndrome
Liver Diseases
Leukemic Infiltration
Living Donors
Liver Cirrhosis
Atrophy
Fibrosis
Transplantation
Transient Myeloproliferative Syndrome
Liver

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

Successful liver transplantation for transient abnormal myelopoiesis-associated liver failure. / Yasuoka, Kazuaki; Inoue, Hirosuke; Tanaka, Koichi; Fujiyoshi, Junko; Matsushita, Yuki; Ochiai, Masayuki; Koga, Yuhki; Matsuura, Toshiharu; Taguchi, Tomoaki; Ohga, Shouichi.

In: Neonatology, Vol. 112, No. 2, 01.08.2017, p. 159-162.

Research output: Contribution to journalArticle

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AU - Ochiai, Masayuki

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