Successful management of cryptococcosis of the bilateral adrenal glands and liver by unilateral adrenalectomy with antifungal agents: A case report

Yayoi Matsuda, Hisaya Kawate, Yuka Okishige, Ichiro Abe, Masahiro Adachi, Keizo Ohnaka, Naoichi Satoh, Junichi Inokuchi, Katsunori Tatsugami, Seiji Naito, Masatoshi Nomura, Ryoichi Takayanagi

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Abstract

Background: Cryptococcus species usually affect the central nervous system and lungs in immunocompromised hosts. Although the adrenal glands can be involved in disseminated cryptococcosis, primary adrenal insufficiency caused by the fungal infection is uncommon.Case presentation: We present a case of primary adrenal insufficiency with bilateral adrenal masses and liver invasion in a 43-year-old man with mild type 2 diabetes mellitus. Cryptococcosis was diagnosed by fine-needle aspiration biopsy of the liver mass. The serum cryptococcal antigen titer was elevated to 1:256. After 6 months of antifungal therapy with fluconazole and amphotericin B, the size of the liver mass was decreased, but no significant changes were observed in the bilateral adrenal masses and the serum cryptococcal antigen titer remained elevated at 1:128. To control the cryptococcosis, a laparoscopic left adrenalectomy was performed, followed by antifungal therapy. After the unilateral adrenalectomy, the size of the remaining right adrenal mass was reduced and the serum cryptococcal antigen titer declined to 1:4.Conclusions: This is the first report describing adrenal cryptococcosis with adrenal insufficiency and liver invasion without central nervous system involvement. Adrenal cryptococcosis should be considered in the differential diagnosis for patients with bilateral adrenal masses with primary adrenal deficiency. Unilateral adrenalectomy was quite effective in controlling the cryptococcosis in this case. Even in patients with bilateral adrenal cryptococcosis, unilateral adrenalectomy should be an option for treatment of disseminated cryptococcosis.

Original languageEnglish
Article number340
JournalBMC Infectious Diseases
Volume11
DOIs
Publication statusPublished - Dec 14 2011

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Cryptococcosis
Antifungal Agents
Adrenalectomy
Adrenal Glands
Liver
Addison Disease
Antigens
Central Nervous System
Serum
Cryptococcus
Adrenal Insufficiency
Mycoses
Fluconazole
Immunocompromised Host
Amphotericin B
Fine Needle Biopsy
Type 2 Diabetes Mellitus
Differential Diagnosis
Therapeutics
Lung

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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Successful management of cryptococcosis of the bilateral adrenal glands and liver by unilateral adrenalectomy with antifungal agents : A case report. / Matsuda, Yayoi; Kawate, Hisaya; Okishige, Yuka; Abe, Ichiro; Adachi, Masahiro; Ohnaka, Keizo; Satoh, Naoichi; Inokuchi, Junichi; Tatsugami, Katsunori; Naito, Seiji; Nomura, Masatoshi; Takayanagi, Ryoichi.

In: BMC Infectious Diseases, Vol. 11, 340, 14.12.2011.

Research output: Contribution to journalArticle

Matsuda, Yayoi ; Kawate, Hisaya ; Okishige, Yuka ; Abe, Ichiro ; Adachi, Masahiro ; Ohnaka, Keizo ; Satoh, Naoichi ; Inokuchi, Junichi ; Tatsugami, Katsunori ; Naito, Seiji ; Nomura, Masatoshi ; Takayanagi, Ryoichi. / Successful management of cryptococcosis of the bilateral adrenal glands and liver by unilateral adrenalectomy with antifungal agents : A case report. In: BMC Infectious Diseases. 2011 ; Vol. 11.
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AU - Abe, Ichiro

AU - Adachi, Masahiro

AU - Ohnaka, Keizo

AU - Satoh, Naoichi

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