Successful outcome with reduced-intensity condition regimen followed by allogeneic hematopoietic stem cell transplantation for relapsed or refractory anaplastic large-cell lymphoma

Reiji Fukano, Tetsuya Mori, Naoto Fujita, Ryoji Kobayashi, Tetsuo Mitsui, Koji Kato, Ritsuro Suzuki, Junji Suzumiya, Takahiro Fukuda, Motohiro Shindo, Nobuo Maseki, Tatsu Shimoyama, Keiko Okada, Masami Inoue, Jiro Inagaki, Yoshiko Hashii, Atsushi Sato, Ken Tabuchi

Research output: Contribution to journalArticle

Abstract

We report a retrospective analysis of 38 patients (age ≤ 30 years) who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT) for relapsed or refractory anaplastic large-cell lymphoma (ALCL). Median follow-up for survivors after undergoing allo-SCT was 72 months (range, 35–96 months). Eight patients received reduced-intensity conditioning (RIC) regimens, including three patients with fludarabine plus melphalan-based regimens and five patients with fludarabine plus busulfan-based regimens. The remaining 30 patients received myeloablative conditioning (MAC) regimens. Median ages in the RIC and MAC groups were 24 and 15 years, respectively. The 5-year overall survival rates in the RIC and MAC groups were 100% and 49%, respectively (P = 0.018). The 5-year event-free survival rates in the RIC and MAC groups were 88% and 43%, respectively (P = 0.039). In the RIC group, four of the eight patients showed residual disease at allo-SCT, but all eight patients survived with complete remission (CR), including one patient with relapse. This result suggests that allo-SCT using the RIC regimen may be effective for relapsed or refractory ALCL in children, adolescents, and young adults, even in non-CR cases.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalInternational journal of hematology
Volume110
Issue number6
DOIs
Publication statusPublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Hematology

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    Fukano, R., Mori, T., Fujita, N., Kobayashi, R., Mitsui, T., Kato, K., Suzuki, R., Suzumiya, J., Fukuda, T., Shindo, M., Maseki, N., Shimoyama, T., Okada, K., Inoue, M., Inagaki, J., Hashii, Y., Sato, A., & Tabuchi, K. (2019). Successful outcome with reduced-intensity condition regimen followed by allogeneic hematopoietic stem cell transplantation for relapsed or refractory anaplastic large-cell lymphoma. International journal of hematology, 110(6), 723-728. https://doi.org/10.1007/s12185-019-02748-1