Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days

Kenichi Todo, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Hidemitsu Adachi, Tomoyuki Kono, Junya Kobayashi, Shiro Yamamoto, Takeshi Morimoto, Shoichi Tani, Michi Kawamoto, Manabu Sakaguchi, Yasushi Ueno, Takeharu Kunieda, Osamu Narumi, Chiaki Sakai, Akira Ishii, Taku Hoshi, Masaomi Koyanagi, Yohei MineharuTatsuya Ishikawa, Yoji Kuramoto, Shinsuke Sato, Nobuyuki Ohara, Koichi Arimura, Hajime Nakamura, Takeo Nishida, Yasufumi Gon, Toshiyuki Fujinaka, Kazuhisa Yoshiya, Haruhiko Kishima, Hideki Mochizuki, Nobuo Kohara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Purpose: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. To assess the long-term effects beyond 90 days, we analyzed the association of successful reperfusion with a temporal change in modified Rankin Scale (mRS) score from 90 days to 1 year after endovascular therapy. Methods: We retrospectively analyzed a database of consecutive patients with acute ischemic stroke who received endovascular therapy between April 2006 and March 2016 at 4 centers. We compared the incidences of improvement and deterioration in patients with successful reperfusion (i.e., modified thrombolysis in cerebral infarction score of 2b or 3) with those in patients with unsuccessful reperfusion. We defined improvement and deterioration as decrease and increase on the mRS score by 1 point or more from 90 days to 1 year after endovascular therapy respectively. Results: A total of 268 patients were included in the current study. The rate of patients with improvement tended to be higher in patients with successful reperfusion than in patients with unsuccessful reperfusion (20% [34/167 patients] vs. 12% [12/101], p = 0.07). The rate of patients with deterioration was lower in patients with successful reperfusion than in patients with unsuccessful reperfusion (25% [42/167] vs. 42% [42/101], p < 0.01). After adjustment for confounders, successful reperfusion was associated with improvement (adjusted OR 2.65; 95% CI 1.23-5.73; p < 0.05) and deterioration (adjusted OR 0.33; 95% CI 0.18-0.62; p < 0.01), independent of the 90-day mRS score. Conclusions: Successful reperfusion has further beneficial legacy effects on long-term outcomes beyond 90 days after stroke.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalCerebrovascular Diseases
Volume47
Issue number3-4
DOIs
Publication statusPublished - Jul 1 2019

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Reperfusion
Therapeutics
Stroke
Cerebral Infarction
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Todo, K., Sakai, N., Imamura, H., Yamagami, H., Adachi, H., Kono, T., ... Kohara, N. (2019). Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days. Cerebrovascular Diseases, 47(3-4), 127-134. https://doi.org/10.1159/000499190

Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days. / Todo, Kenichi; Sakai, Nobuyuki; Imamura, Hirotoshi; Yamagami, Hiroshi; Adachi, Hidemitsu; Kono, Tomoyuki; Kobayashi, Junya; Yamamoto, Shiro; Morimoto, Takeshi; Tani, Shoichi; Kawamoto, Michi; Sakaguchi, Manabu; Ueno, Yasushi; Kunieda, Takeharu; Narumi, Osamu; Sakai, Chiaki; Ishii, Akira; Hoshi, Taku; Koyanagi, Masaomi; Mineharu, Yohei; Ishikawa, Tatsuya; Kuramoto, Yoji; Sato, Shinsuke; Ohara, Nobuyuki; Arimura, Koichi; Nakamura, Hajime; Nishida, Takeo; Gon, Yasufumi; Fujinaka, Toshiyuki; Yoshiya, Kazuhisa; Kishima, Haruhiko; Mochizuki, Hideki; Kohara, Nobuo.

In: Cerebrovascular Diseases, Vol. 47, No. 3-4, 01.07.2019, p. 127-134.

Research output: Contribution to journalArticle

Todo, K, Sakai, N, Imamura, H, Yamagami, H, Adachi, H, Kono, T, Kobayashi, J, Yamamoto, S, Morimoto, T, Tani, S, Kawamoto, M, Sakaguchi, M, Ueno, Y, Kunieda, T, Narumi, O, Sakai, C, Ishii, A, Hoshi, T, Koyanagi, M, Mineharu, Y, Ishikawa, T, Kuramoto, Y, Sato, S, Ohara, N, Arimura, K, Nakamura, H, Nishida, T, Gon, Y, Fujinaka, T, Yoshiya, K, Kishima, H, Mochizuki, H & Kohara, N 2019, 'Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days', Cerebrovascular Diseases, vol. 47, no. 3-4, pp. 127-134. https://doi.org/10.1159/000499190
Todo, Kenichi ; Sakai, Nobuyuki ; Imamura, Hirotoshi ; Yamagami, Hiroshi ; Adachi, Hidemitsu ; Kono, Tomoyuki ; Kobayashi, Junya ; Yamamoto, Shiro ; Morimoto, Takeshi ; Tani, Shoichi ; Kawamoto, Michi ; Sakaguchi, Manabu ; Ueno, Yasushi ; Kunieda, Takeharu ; Narumi, Osamu ; Sakai, Chiaki ; Ishii, Akira ; Hoshi, Taku ; Koyanagi, Masaomi ; Mineharu, Yohei ; Ishikawa, Tatsuya ; Kuramoto, Yoji ; Sato, Shinsuke ; Ohara, Nobuyuki ; Arimura, Koichi ; Nakamura, Hajime ; Nishida, Takeo ; Gon, Yasufumi ; Fujinaka, Toshiyuki ; Yoshiya, Kazuhisa ; Kishima, Haruhiko ; Mochizuki, Hideki ; Kohara, Nobuo. / Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days. In: Cerebrovascular Diseases. 2019 ; Vol. 47, No. 3-4. pp. 127-134.
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T1 - Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days

AU - Todo, Kenichi

AU - Sakai, Nobuyuki

AU - Imamura, Hirotoshi

AU - Yamagami, Hiroshi

AU - Adachi, Hidemitsu

AU - Kono, Tomoyuki

AU - Kobayashi, Junya

AU - Yamamoto, Shiro

AU - Morimoto, Takeshi

AU - Tani, Shoichi

AU - Kawamoto, Michi

AU - Sakaguchi, Manabu

AU - Ueno, Yasushi

AU - Kunieda, Takeharu

AU - Narumi, Osamu

AU - Sakai, Chiaki

AU - Ishii, Akira

AU - Hoshi, Taku

AU - Koyanagi, Masaomi

AU - Mineharu, Yohei

AU - Ishikawa, Tatsuya

AU - Kuramoto, Yoji

AU - Sato, Shinsuke

AU - Ohara, Nobuyuki

AU - Arimura, Koichi

AU - Nakamura, Hajime

AU - Nishida, Takeo

AU - Gon, Yasufumi

AU - Fujinaka, Toshiyuki

AU - Yoshiya, Kazuhisa

AU - Kishima, Haruhiko

AU - Mochizuki, Hideki

AU - Kohara, Nobuo

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background and Purpose: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. To assess the long-term effects beyond 90 days, we analyzed the association of successful reperfusion with a temporal change in modified Rankin Scale (mRS) score from 90 days to 1 year after endovascular therapy. Methods: We retrospectively analyzed a database of consecutive patients with acute ischemic stroke who received endovascular therapy between April 2006 and March 2016 at 4 centers. We compared the incidences of improvement and deterioration in patients with successful reperfusion (i.e., modified thrombolysis in cerebral infarction score of 2b or 3) with those in patients with unsuccessful reperfusion. We defined improvement and deterioration as decrease and increase on the mRS score by 1 point or more from 90 days to 1 year after endovascular therapy respectively. Results: A total of 268 patients were included in the current study. The rate of patients with improvement tended to be higher in patients with successful reperfusion than in patients with unsuccessful reperfusion (20% [34/167 patients] vs. 12% [12/101], p = 0.07). The rate of patients with deterioration was lower in patients with successful reperfusion than in patients with unsuccessful reperfusion (25% [42/167] vs. 42% [42/101], p < 0.01). After adjustment for confounders, successful reperfusion was associated with improvement (adjusted OR 2.65; 95% CI 1.23-5.73; p < 0.05) and deterioration (adjusted OR 0.33; 95% CI 0.18-0.62; p < 0.01), independent of the 90-day mRS score. Conclusions: Successful reperfusion has further beneficial legacy effects on long-term outcomes beyond 90 days after stroke.

AB - Background and Purpose: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. To assess the long-term effects beyond 90 days, we analyzed the association of successful reperfusion with a temporal change in modified Rankin Scale (mRS) score from 90 days to 1 year after endovascular therapy. Methods: We retrospectively analyzed a database of consecutive patients with acute ischemic stroke who received endovascular therapy between April 2006 and March 2016 at 4 centers. We compared the incidences of improvement and deterioration in patients with successful reperfusion (i.e., modified thrombolysis in cerebral infarction score of 2b or 3) with those in patients with unsuccessful reperfusion. We defined improvement and deterioration as decrease and increase on the mRS score by 1 point or more from 90 days to 1 year after endovascular therapy respectively. Results: A total of 268 patients were included in the current study. The rate of patients with improvement tended to be higher in patients with successful reperfusion than in patients with unsuccessful reperfusion (20% [34/167 patients] vs. 12% [12/101], p = 0.07). The rate of patients with deterioration was lower in patients with successful reperfusion than in patients with unsuccessful reperfusion (25% [42/167] vs. 42% [42/101], p < 0.01). After adjustment for confounders, successful reperfusion was associated with improvement (adjusted OR 2.65; 95% CI 1.23-5.73; p < 0.05) and deterioration (adjusted OR 0.33; 95% CI 0.18-0.62; p < 0.01), independent of the 90-day mRS score. Conclusions: Successful reperfusion has further beneficial legacy effects on long-term outcomes beyond 90 days after stroke.

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