Successful steroid treatment in a patient with membranoproliferative glomerulonephritis associated with hepatitis C virus

Toru Sanai, Izumi Watanabe, Tadashi Hirano, Masaru Nakayama, Hironori Sakai, Noriko Uesugi, Kohsuke Masutani, Ritsuko Katafuchi, Hideki Hirakata, Mitsuo Iida

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Abstract

Thirteen years ago, a 65-year-old woman was diagnosed to have chronic active hepatitis with hepatitis C virus. After starting interferonα administration, she noticed edema and hypoalbuminemia. Renal biopsy revealed mesangial proliferation with focal endocapillary proliferation, and double contour of the glomerular basement membrane due to mesangial interposition. Interferonα was discontinued, and proteinuria and edema gradually decreased. She was re-admitted due to a relapse of proteinuria 8 years later. Biopsy revealed moderate mesangial and endcapillary proliferation presenting a lobular pattern, in addition to the presence of hyaline thrombi. Granular staining of immunoglobulin M and of C3 in capillary walls were detected. Since cryoglobulinemia was positive, a final diagnosis of cryoglobulinemic membranoproliferative glomerulonephritis was made. Prednisolone was started with an initial dose of 20 mg/day. Proteinuria and hypoalbuminemia improved, and prednisolone was tapered to 5 mg/day 9 months after the 2nd renal biopsy. The hepatitis C virus-RNA titer fluctuated.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalInternational Urology and Nephrology
Volume41
Issue number1
DOIs
Publication statusPublished - Mar 2009

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

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    Sanai, T., Watanabe, I., Hirano, T., Nakayama, M., Sakai, H., Uesugi, N., Masutani, K., Katafuchi, R., Hirakata, H., & Iida, M. (2009). Successful steroid treatment in a patient with membranoproliferative glomerulonephritis associated with hepatitis C virus. International Urology and Nephrology, 41(1), 179-183. https://doi.org/10.1007/s11255-007-9322-7