Successful therapy with argatroban for superior mesenteric vein thrombosis in a patient with congenital antithrombin deficiency

Tsuyoshi Muta, Takashi Okamura, Masahiko Kawamoto, Hitoshi Ichimiya, Motoko Yamanaka, Yui Wada, Michiyo Urata, Yuzo Kayamori, Naotaka Hamasaki, Koji Kato, Testuya Eto, Hisashi Gondo, Tsunefumi Shibuya

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A 38-year-old woman was admitted with superior mesenteric vein (SMV) thrombosis, which was refractory to anticoagulation therapy. The plasma antithrombin activity was decreased and hardly compensated by concentrated antithrombin preparation due to high consumption rate. However, successful anticoagulation was achieved by administration of direct thrombin inhibitor, argatroban. Family studies of antithrombin activity revealed that she had type I congenital antithrombin deficiency. A novel heterozygous mutation in the gene for antithrombin (single nucleotide T insertion at 7916 and 7917, Glu 272 to stop in exon 4) was identified. Argatroban administration would be effective in the treatment of congenital antithrombin deficiency with SMV thrombosis.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalEuropean Journal of Haematology
Volume75
Issue number2
DOIs
Publication statusPublished - Aug 2005

All Science Journal Classification (ASJC) codes

  • Hematology

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