TY - JOUR
T1 - Successful treatment of an infected wound in infants by a combination of negative pressure wound therapy and arginine supplementation
AU - Masumoto, Kouji
AU - Nagata, Kouji
AU - Oka, Yoichiro
AU - Kai, Hiroki
AU - Yamaguchi, Sadako
AU - Wada, Mika
AU - Kusuda, Tsuyoshi
AU - Hara, Toshiro
AU - Hirose, Shin ichi
AU - Iwasaki, Akinori
AU - Taguchi, Tomoaki
PY - 2011/11
Y1 - 2011/11
N2 - Objective: Wound dehiscence caused by surgical site infection (SSI) presents a complicated problem. Negative pressure wound therapy (NPWT) was developed to treat wound dehiscence. Nutritional treatment using arginine has also been recently shown to be effective for the treatment of pressure ulcers. Therefore, wound complications due to SSI were treated using NPWT combined with nutritional therapy with an arginine-rich supplement (ARS). Methods: Six pediatric patients with wound dehiscence due to SSI received this combined therapy. Results: The average age of the patients was 12.2 mo. The operations that these patients underwent included laryngotracheal separation, radical operation for spinal bifida, gastrostomy, colostomy, anorectoplasty, and tumor extirpation. A local wound infection induced wound dehiscence in all patients. Therefore, NPWT was introduced with an enteral administration of ARS. All wounds completely healed within 1 mo after the introduction of this combined therapy without any other complications from the NPWT or ARS. A follow-up study at 6 mo after this therapy was completed showed no complications associated with the wounds. Conclusion: This combination therapy using NPWT and ARS administration was effective in inducing early healing of infected wound complications after surgery.
AB - Objective: Wound dehiscence caused by surgical site infection (SSI) presents a complicated problem. Negative pressure wound therapy (NPWT) was developed to treat wound dehiscence. Nutritional treatment using arginine has also been recently shown to be effective for the treatment of pressure ulcers. Therefore, wound complications due to SSI were treated using NPWT combined with nutritional therapy with an arginine-rich supplement (ARS). Methods: Six pediatric patients with wound dehiscence due to SSI received this combined therapy. Results: The average age of the patients was 12.2 mo. The operations that these patients underwent included laryngotracheal separation, radical operation for spinal bifida, gastrostomy, colostomy, anorectoplasty, and tumor extirpation. A local wound infection induced wound dehiscence in all patients. Therefore, NPWT was introduced with an enteral administration of ARS. All wounds completely healed within 1 mo after the introduction of this combined therapy without any other complications from the NPWT or ARS. A follow-up study at 6 mo after this therapy was completed showed no complications associated with the wounds. Conclusion: This combination therapy using NPWT and ARS administration was effective in inducing early healing of infected wound complications after surgery.
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U2 - 10.1016/j.nut.2011.01.006
DO - 10.1016/j.nut.2011.01.006
M3 - Article
C2 - 21621390
AN - SCOPUS:80053437600
VL - 27
SP - 1141
EP - 1145
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 11-12
ER -