Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia

Junichiro Yuda, Koji Kato, Yoshikane Kikushige, Kiyofumi Ohkusu, Makiko Kiyosuke, Keiji Sakamoto, Seido Oku, Noriko Miyake, Masako Kadowaki, Tadafumi Iino, Kazuki Tanimoto, Katsuto Takenaka, Hiromi Iwasaki, Toshihiro Miyamoto, Nobuyuki Shimono, Takanori Teshima, Koichi Akashi

Research output: Contribution to journalArticle

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Abstract

Zygomycosis is a lethal and invasive mold infection that is often associated with hematological malignancies. The keys for successful treatment include making a rapid diagnosis and appropriately administering an-tifungal agents. We herein report the early diagnosis of a case of zygomycosis in a patient with acute myeloid leukemia using a deoxyribonucleic acid sequence analysis. We successfully performed allogeneic he-matopoietic stem cell transplantation with the use of high-dose liposomal amphotericin B and granulocyte transfusion.

Original languageEnglish
Pages (from-to)1087-1091
Number of pages5
JournalInternal Medicine
Volume53
Issue number10
DOIs
Publication statusPublished - Jan 1 2014

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Zygomycosis
Acute Myeloid Leukemia
Stem Cell Transplantation
Hematologic Neoplasms
Granulocytes
Sequence Analysis
Early Diagnosis
Fungi
DNA
Therapeutics
Infection
liposomal amphotericin B

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia. / Yuda, Junichiro; Kato, Koji; Kikushige, Yoshikane; Ohkusu, Kiyofumi; Kiyosuke, Makiko; Sakamoto, Keiji; Oku, Seido; Miyake, Noriko; Kadowaki, Masako; Iino, Tadafumi; Tanimoto, Kazuki; Takenaka, Katsuto; Iwasaki, Hiromi; Miyamoto, Toshihiro; Shimono, Nobuyuki; Teshima, Takanori; Akashi, Koichi.

In: Internal Medicine, Vol. 53, No. 10, 01.01.2014, p. 1087-1091.

Research output: Contribution to journalArticle

Yuda, Junichiro ; Kato, Koji ; Kikushige, Yoshikane ; Ohkusu, Kiyofumi ; Kiyosuke, Makiko ; Sakamoto, Keiji ; Oku, Seido ; Miyake, Noriko ; Kadowaki, Masako ; Iino, Tadafumi ; Tanimoto, Kazuki ; Takenaka, Katsuto ; Iwasaki, Hiromi ; Miyamoto, Toshihiro ; Shimono, Nobuyuki ; Teshima, Takanori ; Akashi, Koichi. / Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia. In: Internal Medicine. 2014 ; Vol. 53, No. 10. pp. 1087-1091.
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