Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil

Kazuhiko Higashioka, Kenji Yoshida, Kensuke Oryoji, Kazuo Kamada, Shinichi Mizuki, Hiroshi Tsukamoto, Eisuke Yokota, Koichi Akashi

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Abstract

We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.

Original languageEnglish
Pages (from-to)2255-2259
Number of pages5
JournalInternal Medicine
Volume54
Issue number17
DOIs
Publication statusPublished - Sep 1 2015

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All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Higashioka, K., Yoshida, K., Oryoji, K., Kamada, K., Mizuki, S., Tsukamoto, H., ... Akashi, K. (2015). Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil. Internal Medicine, 54(17), 2255-2259. https://doi.org/10.2169/internalmedicine.54.4582