Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Atsushi Nonami, Katsuto Takenaka, Chinatsu Sumida, Kumiko Aizawa, Kenjiro Kamezaki, Toshihiro Miyamoto, Naoki Harada, Koji Nagafuji, Takanori Teshima, Mine Harada

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

Original languageEnglish
Pages (from-to)1753-1756
Number of pages4
JournalInternal Medicine
Volume46
Issue number20
DOIs
Publication statusPublished - Oct 15 2007

Fingerprint

Intestinal Diseases
Myelodysplastic Syndromes
Fetal Blood
Transplantation
Therapeutics
Immunosuppressive Agents
Rare Diseases
Hemorrhage
Infection

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation. / Nonami, Atsushi; Takenaka, Katsuto; Sumida, Chinatsu; Aizawa, Kumiko; Kamezaki, Kenjiro; Miyamoto, Toshihiro; Harada, Naoki; Nagafuji, Koji; Teshima, Takanori; Harada, Mine.

In: Internal Medicine, Vol. 46, No. 20, 15.10.2007, p. 1753-1756.

Research output: Contribution to journalArticle

Nonami, Atsushi ; Takenaka, Katsuto ; Sumida, Chinatsu ; Aizawa, Kumiko ; Kamezaki, Kenjiro ; Miyamoto, Toshihiro ; Harada, Naoki ; Nagafuji, Koji ; Teshima, Takanori ; Harada, Mine. / Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation. In: Internal Medicine. 2007 ; Vol. 46, No. 20. pp. 1753-1756.
@article{17e38de5a4c6492db8eb4f41ef91e31f,
title = "Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Beh{\cc}et's disease by up-front cord blood transplantation",
abstract = "Beh{\cc}et's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Beh{\cc}et's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Beh{\cc}et's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Beh{\cc}et's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Beh{\cc}et's disease.",
author = "Atsushi Nonami and Katsuto Takenaka and Chinatsu Sumida and Kumiko Aizawa and Kenjiro Kamezaki and Toshihiro Miyamoto and Naoki Harada and Koji Nagafuji and Takanori Teshima and Mine Harada",
year = "2007",
month = "10",
day = "15",
doi = "10.2169/internalmedicine.46.0291",
language = "English",
volume = "46",
pages = "1753--1756",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "20",

}

TY - JOUR

T1 - Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

AU - Nonami, Atsushi

AU - Takenaka, Katsuto

AU - Sumida, Chinatsu

AU - Aizawa, Kumiko

AU - Kamezaki, Kenjiro

AU - Miyamoto, Toshihiro

AU - Harada, Naoki

AU - Nagafuji, Koji

AU - Teshima, Takanori

AU - Harada, Mine

PY - 2007/10/15

Y1 - 2007/10/15

N2 - Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

AB - Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

UR - http://www.scopus.com/inward/record.url?scp=35748930610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748930610&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.46.0291

DO - 10.2169/internalmedicine.46.0291

M3 - Article

C2 - 17938534

AN - SCOPUS:35748930610

VL - 46

SP - 1753

EP - 1756

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 20

ER -