Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Atsushi Nonami; Katsuto Takenaka; Chinatsu Sumida; Kumiko Aizawa; Kenjiro Kamezaki; Toshihiro Miyamoto; Naoki Harada; Koji Nagafuji; Takanori Teshima; Mine Harada

doi:10.2169/internalmedicine.46.0291

Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Atsushi Nonami, Katsuto Takenaka, Chinatsu Sumida, Kumiko Aizawa, Kenjiro Kamezaki, Toshihiro Miyamoto, Naoki Harada, Koji Nagafuji, Takanori Teshima, Mine Harada

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

Original language	English
Pages (from-to)	1753-1756
Number of pages	4
Journal	Internal Medicine
Volume	46
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.46.0291
Publication status	Published - Oct 15 2007

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.46.0291

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title = "Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Beh{\c c}et's disease by up-front cord blood transplantation",

abstract = "Beh{\c c}et's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Beh{\c c}et's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Beh{\c c}et's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Beh{\c c}et's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Beh{\c c}et's disease.",

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T1 - Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

AU - Nonami, Atsushi

AU - Takenaka, Katsuto

AU - Sumida, Chinatsu

AU - Aizawa, Kumiko

AU - Kamezaki, Kenjiro

AU - Miyamoto, Toshihiro

AU - Harada, Naoki

AU - Nagafuji, Koji

AU - Teshima, Takanori

AU - Harada, Mine

PY - 2007/10/15

Y1 - 2007/10/15

N2 - Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

AB - Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.

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Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Abstract

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