Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

Masanori Makita, Yoshinobu Maeda, Katsuto Takenaka, Katsuji Shinagawa, Kazutaka Sunami, Yasushi Hiramatsu, Nobuharu Fujii, Fumihiko Ishimaru, Kazuma Ikeda, Kenji Niiya, Tadashi Yoshino, Mine Harada

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Abstract

We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalInternational Journal of Hematology
Volume76
Issue number1
DOIs
Publication statusPublished - Jul 1 2002

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Peripheral Blood Stem Cell Transplantation
Natural Killer Cells
Cyclosporine
Lymphoma
Leukocytes
Tissue Donors
Chemoradiotherapy
Therapeutics
Transplantation
Transplants
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Hematology

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Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions. / Makita, Masanori; Maeda, Yoshinobu; Takenaka, Katsuto; Shinagawa, Katsuji; Sunami, Kazutaka; Hiramatsu, Yasushi; Fujii, Nobuharu; Ishimaru, Fumihiko; Ikeda, Kazuma; Niiya, Kenji; Yoshino, Tadashi; Harada, Mine.

In: International Journal of Hematology, Vol. 76, No. 1, 01.07.2002, p. 94-97.

Research output: Contribution to journalArticle

Makita, M, Maeda, Y, Takenaka, K, Shinagawa, K, Sunami, K, Hiramatsu, Y, Fujii, N, Ishimaru, F, Ikeda, K, Niiya, K, Yoshino, T & Harada, M 2002, 'Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions', International Journal of Hematology, vol. 76, no. 1, pp. 94-97. https://doi.org/10.1007/BF02982726
Makita, Masanori ; Maeda, Yoshinobu ; Takenaka, Katsuto ; Shinagawa, Katsuji ; Sunami, Kazutaka ; Hiramatsu, Yasushi ; Fujii, Nobuharu ; Ishimaru, Fumihiko ; Ikeda, Kazuma ; Niiya, Kenji ; Yoshino, Tadashi ; Harada, Mine. / Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions. In: International Journal of Hematology. 2002 ; Vol. 76, No. 1. pp. 94-97.
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