Successful treatment of rapidly progressive interstitial pneumonia with autologous peripheral blood stem cell transplantation in a patient with dermatomyositis

Kensuke Oryoji, Daisuke Himeji, Kouji Nagafuji, Takahiko Horiuchi, Hiroshi Tsukamoto, Hisashi Gondo, Mine Harada

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22 Citations (Scopus)

Abstract

Aggressive autoimmune diseases are often treated by intensive immunosuppressive treatment such as high-dose methylprednisolone and intravenous cyclophosphamide. Autologous hematopoietic stem cell transplantation can facilitate high-dose immunosuppressive therapy (HDIT), which is myeloablative. We describe a 54-year-old female patient with rapidly progressive and refractory interstitial pneumonia due to dermatomyositis, which was successfully treated with high-dose cyclophosphamide and autologous blood stem cell transplantation. Following transplantation, dyspnea disappeared, and arterial blood gas analysis and respiratory function test showed marked improvement. This improvement was confirmed by diminished interstitial shadows on chest X-ray and computed tomography scans. Eighteen months after transplantation, the patient is doing well without symptoms and signs of interstitial pneumonia.

Original languageEnglish
Pages (from-to)637-640
Number of pages4
JournalClinical Rheumatology
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 1 2005

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All Science Journal Classification (ASJC) codes

  • Rheumatology

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