Sudden sound-induced death in magnesium-deficient rats after repetitive episodes of seizures result from brain dysfunction.

M. Nakamura, S. Abe, Y. Goto, A. Chishaki

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To clarify the changes occurring in EEG and ECG from seizure induction to sudden death, 25 weanling male Sprague-Dawley rats were fed a severely Mg-deficient diet for 18 days. In nine of 25 Mg-deficient rats, both EEG and ECG were recorded from the beginning of seizures induction until sudden death. When flattening of EEG became after seizure occurrence, all nine Mg-deficient rats did not recover and death occurred within a few minutes. These results may support the idea that sudden death in Mg-deficient rats resulted from brain dysfunction after repetitive episodes of noise-induced seizures and not from simple apnoea due to tonic contraction of respiratory muscle.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalMagnesium research : official organ of the International Society for the Development of Research on Magnesium
Issue number1
Publication statusPublished - Mar 1995


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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