SU‐E‐T‐456: Prospective Investigation of Feasibility of Three‐Dimensional Treatment Planning of Intracavitary Brachytherapy for Cervical Cancer Based On Computed Tomography Images

O. Yoshifumi, Hidetaka Arimura, H. Yoshiyuki, S. Yasumasa, T. Masahiko, I. Mutsumi, F. Noboru, N. Masayuki, H. Hideki

Research output: Contribution to journalArticle

Abstract

Purpose: Our aim of this study was to prospectively investigate the feasibility of three‐dimensional (3D) treatment planning of intracavitary brachytherapy for cervical cancer based on computed tomography (CT) images. Two‐dimensional (2D) treatment planning based on Manchester method and the 3D treatment planning based on Groupe Europeen de Curietherapie‐European Society for Therapeutic Radiology and Oncology recommendations were compared using 2D and 3D‐based dose evaluation indices. Methods: The 2D and 3D treatment plans were made on Oncentra for six patients with stage IB‐IIB cervical cancer, who had undergone intracavitary brachytherapy (five fractions at 6Gy/fraction). Planning CT images were acquired on a 20‐slice CT scanner at the lithotomy position after inserting the applicator. Point A‐based and D90 dose prescriptions were employed for 2D and 3D treatment planning, respectively. The GTV plus 1‐cm margin was defined as a CTV in 3D treatment planning. The two kinds of treatment plans were evaluated by a conformity index (CI), homogeneity index (HI), and tumor control probability (TCP) for CTV, and doses at bladder and rectum evaluation points, D2cc, and normal tissue complication probability (NTCP) for organs at risk (OAR). Results: The CIs for 2D and 3D plans were 2.59 ± 0.59 and 1.12 ± 0.18 (p < 0.05), respectively, and the HIs were 2.18 ± 0.28 (2D) and 1.34 ± 0.27 (3D) (p < 0.05). The bladder D2cc for 2D and 3D plans were 378 ± 58.2 cGy and 504 ±47.2 cGy (p < 0.05), respectively, and the rectum D2cc were 316 ± 58.3 cGy (2D) and 455 ± 36.1 cGy (3D) (p < 0.05). There were no statistical significant differences for the TCP and NTCP. Conclusion: The 3D treatment planning could provide better dose conformity and uniformity in CTVs. The results suggested that the doses for OAR with 2D treatment planning may be underestimated.

Original languageEnglish
Number of pages1
JournalMedical Physics
Volume40
Issue number6
DOIs
Publication statusPublished - Jan 1 2013

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Brachytherapy
Uterine Cervical Neoplasms
Tomography
Organs at Risk
Therapeutics
Rectum
Urinary Bladder
X-Ray Computed Tomography Scanners
Radiation Oncology
Prescriptions
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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SU‐E‐T‐456 : Prospective Investigation of Feasibility of Three‐Dimensional Treatment Planning of Intracavitary Brachytherapy for Cervical Cancer Based On Computed Tomography Images. / Yoshifumi, O.; Arimura, Hidetaka; Yoshiyuki, H.; Yasumasa, S.; Masahiko, T.; Mutsumi, I.; Noboru, F.; Masayuki, N.; Hideki, H.

In: Medical Physics, Vol. 40, No. 6, 01.01.2013.

Research output: Contribution to journalArticle

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abstract = "Purpose: Our aim of this study was to prospectively investigate the feasibility of three‐dimensional (3D) treatment planning of intracavitary brachytherapy for cervical cancer based on computed tomography (CT) images. Two‐dimensional (2D) treatment planning based on Manchester method and the 3D treatment planning based on Groupe Europeen de Curietherapie‐European Society for Therapeutic Radiology and Oncology recommendations were compared using 2D and 3D‐based dose evaluation indices. Methods: The 2D and 3D treatment plans were made on Oncentra for six patients with stage IB‐IIB cervical cancer, who had undergone intracavitary brachytherapy (five fractions at 6Gy/fraction). Planning CT images were acquired on a 20‐slice CT scanner at the lithotomy position after inserting the applicator. Point A‐based and D90 dose prescriptions were employed for 2D and 3D treatment planning, respectively. The GTV plus 1‐cm margin was defined as a CTV in 3D treatment planning. The two kinds of treatment plans were evaluated by a conformity index (CI), homogeneity index (HI), and tumor control probability (TCP) for CTV, and doses at bladder and rectum evaluation points, D2cc, and normal tissue complication probability (NTCP) for organs at risk (OAR). Results: The CIs for 2D and 3D plans were 2.59 ± 0.59 and 1.12 ± 0.18 (p < 0.05), respectively, and the HIs were 2.18 ± 0.28 (2D) and 1.34 ± 0.27 (3D) (p < 0.05). The bladder D2cc for 2D and 3D plans were 378 ± 58.2 cGy and 504 ±47.2 cGy (p < 0.05), respectively, and the rectum D2cc were 316 ± 58.3 cGy (2D) and 455 ± 36.1 cGy (3D) (p < 0.05). There were no statistical significant differences for the TCP and NTCP. Conclusion: The 3D treatment planning could provide better dose conformity and uniformity in CTVs. The results suggested that the doses for OAR with 2D treatment planning may be underestimated.",
author = "O. Yoshifumi and Hidetaka Arimura and H. Yoshiyuki and S. Yasumasa and T. Masahiko and I. Mutsumi and F. Noboru and N. Masayuki and H. Hideki",
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T2 - Prospective Investigation of Feasibility of Three‐Dimensional Treatment Planning of Intracavitary Brachytherapy for Cervical Cancer Based On Computed Tomography Images

AU - Yoshifumi, O.

AU - Arimura, Hidetaka

AU - Yoshiyuki, H.

AU - Yasumasa, S.

AU - Masahiko, T.

AU - Mutsumi, I.

AU - Noboru, F.

AU - Masayuki, N.

AU - Hideki, H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose: Our aim of this study was to prospectively investigate the feasibility of three‐dimensional (3D) treatment planning of intracavitary brachytherapy for cervical cancer based on computed tomography (CT) images. Two‐dimensional (2D) treatment planning based on Manchester method and the 3D treatment planning based on Groupe Europeen de Curietherapie‐European Society for Therapeutic Radiology and Oncology recommendations were compared using 2D and 3D‐based dose evaluation indices. Methods: The 2D and 3D treatment plans were made on Oncentra for six patients with stage IB‐IIB cervical cancer, who had undergone intracavitary brachytherapy (five fractions at 6Gy/fraction). Planning CT images were acquired on a 20‐slice CT scanner at the lithotomy position after inserting the applicator. Point A‐based and D90 dose prescriptions were employed for 2D and 3D treatment planning, respectively. The GTV plus 1‐cm margin was defined as a CTV in 3D treatment planning. The two kinds of treatment plans were evaluated by a conformity index (CI), homogeneity index (HI), and tumor control probability (TCP) for CTV, and doses at bladder and rectum evaluation points, D2cc, and normal tissue complication probability (NTCP) for organs at risk (OAR). Results: The CIs for 2D and 3D plans were 2.59 ± 0.59 and 1.12 ± 0.18 (p < 0.05), respectively, and the HIs were 2.18 ± 0.28 (2D) and 1.34 ± 0.27 (3D) (p < 0.05). The bladder D2cc for 2D and 3D plans were 378 ± 58.2 cGy and 504 ±47.2 cGy (p < 0.05), respectively, and the rectum D2cc were 316 ± 58.3 cGy (2D) and 455 ± 36.1 cGy (3D) (p < 0.05). There were no statistical significant differences for the TCP and NTCP. Conclusion: The 3D treatment planning could provide better dose conformity and uniformity in CTVs. The results suggested that the doses for OAR with 2D treatment planning may be underestimated.

AB - Purpose: Our aim of this study was to prospectively investigate the feasibility of three‐dimensional (3D) treatment planning of intracavitary brachytherapy for cervical cancer based on computed tomography (CT) images. Two‐dimensional (2D) treatment planning based on Manchester method and the 3D treatment planning based on Groupe Europeen de Curietherapie‐European Society for Therapeutic Radiology and Oncology recommendations were compared using 2D and 3D‐based dose evaluation indices. Methods: The 2D and 3D treatment plans were made on Oncentra for six patients with stage IB‐IIB cervical cancer, who had undergone intracavitary brachytherapy (five fractions at 6Gy/fraction). Planning CT images were acquired on a 20‐slice CT scanner at the lithotomy position after inserting the applicator. Point A‐based and D90 dose prescriptions were employed for 2D and 3D treatment planning, respectively. The GTV plus 1‐cm margin was defined as a CTV in 3D treatment planning. The two kinds of treatment plans were evaluated by a conformity index (CI), homogeneity index (HI), and tumor control probability (TCP) for CTV, and doses at bladder and rectum evaluation points, D2cc, and normal tissue complication probability (NTCP) for organs at risk (OAR). Results: The CIs for 2D and 3D plans were 2.59 ± 0.59 and 1.12 ± 0.18 (p < 0.05), respectively, and the HIs were 2.18 ± 0.28 (2D) and 1.34 ± 0.27 (3D) (p < 0.05). The bladder D2cc for 2D and 3D plans were 378 ± 58.2 cGy and 504 ±47.2 cGy (p < 0.05), respectively, and the rectum D2cc were 316 ± 58.3 cGy (2D) and 455 ± 36.1 cGy (3D) (p < 0.05). There were no statistical significant differences for the TCP and NTCP. Conclusion: The 3D treatment planning could provide better dose conformity and uniformity in CTVs. The results suggested that the doses for OAR with 2D treatment planning may be underestimated.

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