Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study

Zhenjie Wang, Kazuhiro Uchida, Keizo Ohnaka, Makiko Morita, Kengo Toyomura, Suminori Kono, Takashi Ueki, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Reiji Terasaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective. A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case-control study in Japan. Methods. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Results. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. Conclusion. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.

Original languageEnglish
Pages (from-to)581-588
Number of pages8
JournalScandinavian Journal of Gastroenterology
Volume49
Issue number5
DOIs
Publication statusPublished - May 2014

Fingerprint

Sucrose
Colorectal Neoplasms
Logistic Models
Alcohols
Portion Size
Food and Beverages
Confounding Factors (Epidemiology)
Alcohol Drinking
Case-Control Studies
Japan
Carcinogenesis
Body Mass Index
Smoking
Odds Ratio
Interviews
Diet
Food

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Sugars, sucrose and colorectal cancer risk : the Fukuoka colorectal cancer study. / Wang, Zhenjie; Uchida, Kazuhiro; Ohnaka, Keizo; Morita, Makiko; Toyomura, Kengo; Kono, Suminori; Ueki, Takashi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Kenji; Ichimiya, Hitoshi; Terasaka, Reiji.

In: Scandinavian Journal of Gastroenterology, Vol. 49, No. 5, 05.2014, p. 581-588.

Research output: Contribution to journalArticle

Wang, Z, Uchida, K, Ohnaka, K, Morita, M, Toyomura, K, Kono, S, Ueki, T, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Maekawa, T, Yasunami, Y, Takenaka, K, Ichimiya, H & Terasaka, R 2014, 'Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study', Scandinavian Journal of Gastroenterology, vol. 49, no. 5, pp. 581-588. https://doi.org/10.3109/00365521.2013.822091
Wang, Zhenjie ; Uchida, Kazuhiro ; Ohnaka, Keizo ; Morita, Makiko ; Toyomura, Kengo ; Kono, Suminori ; Ueki, Takashi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Maekawa, Takafumi ; Yasunami, Yohichi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Terasaka, Reiji. / Sugars, sucrose and colorectal cancer risk : the Fukuoka colorectal cancer study. In: Scandinavian Journal of Gastroenterology. 2014 ; Vol. 49, No. 5. pp. 581-588.
@article{9e938de71dbc467697be3c18b040d027,
title = "Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study",
abstract = "Objective. A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case-control study in Japan. Methods. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Results. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. Conclusion. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.",
author = "Zhenjie Wang and Kazuhiro Uchida and Keizo Ohnaka and Makiko Morita and Kengo Toyomura and Suminori Kono and Takashi Ueki and Masao Tanaka and Yoshihiro Kakeji and Yoshihiko Maehara and Takeshi Okamura and Koji Ikejiri and Kitaroh Futami and Takafumi Maekawa and Yohichi Yasunami and Kenji Takenaka and Hitoshi Ichimiya and Reiji Terasaka",
year = "2014",
month = "5",
doi = "10.3109/00365521.2013.822091",
language = "English",
volume = "49",
pages = "581--588",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Sugars, sucrose and colorectal cancer risk

T2 - the Fukuoka colorectal cancer study

AU - Wang, Zhenjie

AU - Uchida, Kazuhiro

AU - Ohnaka, Keizo

AU - Morita, Makiko

AU - Toyomura, Kengo

AU - Kono, Suminori

AU - Ueki, Takashi

AU - Tanaka, Masao

AU - Kakeji, Yoshihiro

AU - Maehara, Yoshihiko

AU - Okamura, Takeshi

AU - Ikejiri, Koji

AU - Futami, Kitaroh

AU - Maekawa, Takafumi

AU - Yasunami, Yohichi

AU - Takenaka, Kenji

AU - Ichimiya, Hitoshi

AU - Terasaka, Reiji

PY - 2014/5

Y1 - 2014/5

N2 - Objective. A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case-control study in Japan. Methods. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Results. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. Conclusion. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.

AB - Objective. A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case-control study in Japan. Methods. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Results. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. Conclusion. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.

UR - http://www.scopus.com/inward/record.url?scp=84898929595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898929595&partnerID=8YFLogxK

U2 - 10.3109/00365521.2013.822091

DO - 10.3109/00365521.2013.822091

M3 - Article

C2 - 24716480

AN - SCOPUS:84898929595

VL - 49

SP - 581

EP - 588

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 5

ER -