TY - JOUR
T1 - Sulfated Hyaluronan coating of polyurethanebased implant materials
AU - Kemkemer, Ralf
AU - Athanasopulu, Kiriaki
AU - Caltzidou, Dimitra
AU - Sekishita, Asuka
AU - Kutuzova, Larysa
AU - Lorenz, Günter
AU - Tanaka, Masaru
N1 - Publisher Copyright:
© 2020 by Walter de Gruyter Berlin/Boston 2020.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.
AB - Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.
UR - http://www.scopus.com/inward/record.url?scp=85097221784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097221784&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2020-3115
DO - 10.1515/cdbme-2020-3115
M3 - Article
AN - SCOPUS:85097221784
VL - 6
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
SN - 2364-5504
IS - 3
M1 - 20203115
ER -