11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT

Makoto Nakagawa, Yasuo Kuwabara, Masayuki Sasaki, Hirofumi Koga, Tao Chen, Kouichirou Kaneko, Kazutaka Hayashi, Takato Morioka, Kouji Masuda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalAnnals of Nuclear Medicine
Volume16
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

Fingerprint

Technetium Tc 99m Exametazime
Cerebrovascular Disorders
Fluorodeoxyglucose F18
Single-Photon Emission-Computed Tomography
Methionine
Cerebral Infarction
Hematoma
Brain Diseases
Brain Neoplasms
Differential Diagnosis
Carbon

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

11C-methionine uptake in cerebrovascular disease : A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT. / Nakagawa, Makoto; Kuwabara, Yasuo; Sasaki, Masayuki; Koga, Hirofumi; Chen, Tao; Kaneko, Kouichirou; Hayashi, Kazutaka; Morioka, Takato; Masuda, Kouji.

In: Annals of Nuclear Medicine, Vol. 16, No. 3, 01.01.2002, p. 207-211.

Research output: Contribution to journalArticle

Nakagawa, M, Kuwabara, Y, Sasaki, M, Koga, H, Chen, T, Kaneko, K, Hayashi, K, Morioka, T & Masuda, K 2002, '11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT', Annals of Nuclear Medicine, vol. 16, no. 3, pp. 207-211. https://doi.org/10.1007/BF02996302
Nakagawa, Makoto ; Kuwabara, Yasuo ; Sasaki, Masayuki ; Koga, Hirofumi ; Chen, Tao ; Kaneko, Kouichirou ; Hayashi, Kazutaka ; Morioka, Takato ; Masuda, Kouji. / 11C-methionine uptake in cerebrovascular disease : A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT. In: Annals of Nuclear Medicine. 2002 ; Vol. 16, No. 3. pp. 207-211.
@article{3dad5de4231940b5acf3c4344598944b,
title = "11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT",
abstract = "Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.",
author = "Makoto Nakagawa and Yasuo Kuwabara and Masayuki Sasaki and Hirofumi Koga and Tao Chen and Kouichirou Kaneko and Kazutaka Hayashi and Takato Morioka and Kouji Masuda",
year = "2002",
month = "1",
day = "1",
doi = "10.1007/BF02996302",
language = "English",
volume = "16",
pages = "207--211",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - 11C-methionine uptake in cerebrovascular disease

T2 - A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT

AU - Nakagawa, Makoto

AU - Kuwabara, Yasuo

AU - Sasaki, Masayuki

AU - Koga, Hirofumi

AU - Chen, Tao

AU - Kaneko, Kouichirou

AU - Hayashi, Kazutaka

AU - Morioka, Takato

AU - Masuda, Kouji

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.

AB - Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.

UR - http://www.scopus.com/inward/record.url?scp=0035988923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035988923&partnerID=8YFLogxK

U2 - 10.1007/BF02996302

DO - 10.1007/BF02996302

M3 - Article

C2 - 12126046

AN - SCOPUS:0035988923

VL - 16

SP - 207

EP - 211

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 3

ER -