11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT

Makoto Nakagawa, Yasuo Kuwabara, Masayuki Sasaki, Hirofumi Koga, Tao Chen, Kouichirou Kaneko, Kazutaka Hayashi, Takato Morioka, Kouji Masuda

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22 Citations (Scopus)

Abstract

Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalAnnals of Nuclear Medicine
Volume16
Issue number3
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Nakagawa, M., Kuwabara, Y., Sasaki, M., Koga, H., Chen, T., Kaneko, K., Hayashi, K., Morioka, T., & Masuda, K. (2002). 11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT. Annals of Nuclear Medicine, 16(3), 207-211. https://doi.org/10.1007/BF02996302