125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution

Fumihiko Yamamoto; Eri Kuwano; Tetsuo Kaneshiro; Shigeki Sasaki; Minoru Maeda

doi:10.1002/jlcr.714

¹²⁵I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution

Fumihiko Yamamoto, Eri Kuwano, Tetsuo Kaneshiro, Shigeki Sasaki, Minoru Maeda

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Three ¹²⁵I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with ¹⁴C-labeled ascorbic acid and 6-deoxy-6-[¹⁸F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry.

Original language	English
Pages (from-to)	737-750
Number of pages	14
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	46
Issue number	8
DOIs	https://doi.org/10.1002/jlcr.714
Publication status	Published - Jul 2003

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.714

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¹²⁵I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid : Synthesis and preliminary tissue distribution. / Yamamoto, Fumihiko; Kuwano, Eri; Kaneshiro, Tetsuo; Sasaki, Shigeki; Maeda, Minoru.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, No. 8, 07.2003, p. 737-750.

Research output: Contribution to journal › Article › peer-review

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¹²⁵I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution

Abstract

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