Abstract
Three 125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry.
Original language | English |
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Pages (from-to) | 737-750 |
Number of pages | 14 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 46 |
Issue number | 8 |
DOIs | |
Publication status | Published - Jul 2003 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry