Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women

Masako Iwamoto, Katsumi Imai, Hideaki Ohta, Bungo Shirouchi, Masao Sato

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19 Citations (Scopus)

Abstract

Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects. Objective. We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels. Methods. An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7mg/day) was given to 17 moderately obese postmenopausal women. Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4mg per day for 3weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

Original languageEnglish
Article number52
JournalLipids in Health and Disease
Volume11
DOIs
Publication statusPublished - May 15 2012

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Adipokines
Beverages
Serum
Adiponectin
Plasminogen Activator Inhibitor 1
Body Weight Changes
Cryptoxanthins
Molecular weight
Body Mass Index
Obesity
Molecular Weight

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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title = "Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women",
abstract = "Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects. Objective. We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels. Methods. An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7mg/day) was given to 17 moderately obese postmenopausal women. Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4mg per day for 3weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.",
author = "Masako Iwamoto and Katsumi Imai and Hideaki Ohta and Bungo Shirouchi and Masao Sato",
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T1 - Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women

AU - Iwamoto, Masako

AU - Imai, Katsumi

AU - Ohta, Hideaki

AU - Shirouchi, Bungo

AU - Sato, Masao

PY - 2012/5/15

Y1 - 2012/5/15

N2 - Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects. Objective. We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels. Methods. An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7mg/day) was given to 17 moderately obese postmenopausal women. Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4mg per day for 3weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

AB - Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects. Objective. We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels. Methods. An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7mg/day) was given to 17 moderately obese postmenopausal women. Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4mg per day for 3weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

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