Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma

Eiji Tsujita, Akinobu Taketomi, Tomonobu Gion, Yousuke Kuroda, Kazuya Endo, Akihiro Watanabe, Hideaki Nakashima, Shin Ichi Aishima, Shunji Kohnoe, Yoshihiko Maehara

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Objective: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vivo. This study was designed to clarify the expression of MKP-1 in surgically resected hepatocellular carcinoma (HCC). Methods: We reviewed the cases of 77 patients who had undergone initial liver resection for HCC without preoperative treatment. Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues. The correlation between MKP-1 expression and clinical outcome was investigated. Results: Tumor cells were immunohistochemically stained for MKP-1 expression, and the same levels as in normal hepatocytes were detected in 66 (85%) of 77 HCC patients, being decreased in 11 (15%) HCCs. Decreased MKP-1 expression significantly correlated with serum α-fetoprotein levels and tumor size (p < 0.05). The disease-free survival rates in MKP-1-negative and -positive patients were 0 and 31.0% at 5 years, respectively (p < 0.01). The survival rates after a surgical resection in MKP-1-negative and -positive patients were 18.2 and 65.5% at 5 years, respectively (p < 0.01). Conclusions: The MKP-1 expression in HCC was an independent prognostic factor for outcome in HCC patients. In the future, it will be useful to explore whether the phosphatase expression might account for the response to HCC treatments targeting at MARK activation.

Original languageEnglish
Pages (from-to)342-347
Number of pages6
JournalOncology
Volume69
Issue number4
DOIs
Publication statusPublished - Nov 1 2005

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Hepatocellular Carcinoma
Survival Rate
Fetal Proteins
Neoplasms
Mitogen-Activated Protein Kinases
Phosphoric Monoester Hydrolases
Paraffin
Disease-Free Survival
Hepatocytes
Phenotype
Liver
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tsujita, E., Taketomi, A., Gion, T., Kuroda, Y., Endo, K., Watanabe, A., ... Maehara, Y. (2005). Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma. Oncology, 69(4), 342-347. https://doi.org/10.1159/000089766

Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma. / Tsujita, Eiji; Taketomi, Akinobu; Gion, Tomonobu; Kuroda, Yousuke; Endo, Kazuya; Watanabe, Akihiro; Nakashima, Hideaki; Aishima, Shin Ichi; Kohnoe, Shunji; Maehara, Yoshihiko.

In: Oncology, Vol. 69, No. 4, 01.11.2005, p. 342-347.

Research output: Contribution to journalReview article

Tsujita, E, Taketomi, A, Gion, T, Kuroda, Y, Endo, K, Watanabe, A, Nakashima, H, Aishima, SI, Kohnoe, S & Maehara, Y 2005, 'Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma', Oncology, vol. 69, no. 4, pp. 342-347. https://doi.org/10.1159/000089766
Tsujita E, Taketomi A, Gion T, Kuroda Y, Endo K, Watanabe A et al. Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma. Oncology. 2005 Nov 1;69(4):342-347. https://doi.org/10.1159/000089766
Tsujita, Eiji ; Taketomi, Akinobu ; Gion, Tomonobu ; Kuroda, Yousuke ; Endo, Kazuya ; Watanabe, Akihiro ; Nakashima, Hideaki ; Aishima, Shin Ichi ; Kohnoe, Shunji ; Maehara, Yoshihiko. / Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma. In: Oncology. 2005 ; Vol. 69, No. 4. pp. 342-347.
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abstract = "Objective: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vivo. This study was designed to clarify the expression of MKP-1 in surgically resected hepatocellular carcinoma (HCC). Methods: We reviewed the cases of 77 patients who had undergone initial liver resection for HCC without preoperative treatment. Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues. The correlation between MKP-1 expression and clinical outcome was investigated. Results: Tumor cells were immunohistochemically stained for MKP-1 expression, and the same levels as in normal hepatocytes were detected in 66 (85{\%}) of 77 HCC patients, being decreased in 11 (15{\%}) HCCs. Decreased MKP-1 expression significantly correlated with serum α-fetoprotein levels and tumor size (p < 0.05). The disease-free survival rates in MKP-1-negative and -positive patients were 0 and 31.0{\%} at 5 years, respectively (p < 0.01). The survival rates after a surgical resection in MKP-1-negative and -positive patients were 18.2 and 65.5{\%} at 5 years, respectively (p < 0.01). Conclusions: The MKP-1 expression in HCC was an independent prognostic factor for outcome in HCC patients. In the future, it will be useful to explore whether the phosphatase expression might account for the response to HCC treatments targeting at MARK activation.",
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AU - Tsujita, Eiji

AU - Taketomi, Akinobu

AU - Gion, Tomonobu

AU - Kuroda, Yousuke

AU - Endo, Kazuya

AU - Watanabe, Akihiro

AU - Nakashima, Hideaki

AU - Aishima, Shin Ichi

AU - Kohnoe, Shunji

AU - Maehara, Yoshihiko

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N2 - Objective: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vivo. This study was designed to clarify the expression of MKP-1 in surgically resected hepatocellular carcinoma (HCC). Methods: We reviewed the cases of 77 patients who had undergone initial liver resection for HCC without preoperative treatment. Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues. The correlation between MKP-1 expression and clinical outcome was investigated. Results: Tumor cells were immunohistochemically stained for MKP-1 expression, and the same levels as in normal hepatocytes were detected in 66 (85%) of 77 HCC patients, being decreased in 11 (15%) HCCs. Decreased MKP-1 expression significantly correlated with serum α-fetoprotein levels and tumor size (p < 0.05). The disease-free survival rates in MKP-1-negative and -positive patients were 0 and 31.0% at 5 years, respectively (p < 0.01). The survival rates after a surgical resection in MKP-1-negative and -positive patients were 18.2 and 65.5% at 5 years, respectively (p < 0.01). Conclusions: The MKP-1 expression in HCC was an independent prognostic factor for outcome in HCC patients. In the future, it will be useful to explore whether the phosphatase expression might account for the response to HCC treatments targeting at MARK activation.

AB - Objective: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vivo. This study was designed to clarify the expression of MKP-1 in surgically resected hepatocellular carcinoma (HCC). Methods: We reviewed the cases of 77 patients who had undergone initial liver resection for HCC without preoperative treatment. Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues. The correlation between MKP-1 expression and clinical outcome was investigated. Results: Tumor cells were immunohistochemically stained for MKP-1 expression, and the same levels as in normal hepatocytes were detected in 66 (85%) of 77 HCC patients, being decreased in 11 (15%) HCCs. Decreased MKP-1 expression significantly correlated with serum α-fetoprotein levels and tumor size (p < 0.05). The disease-free survival rates in MKP-1-negative and -positive patients were 0 and 31.0% at 5 years, respectively (p < 0.01). The survival rates after a surgical resection in MKP-1-negative and -positive patients were 18.2 and 65.5% at 5 years, respectively (p < 0.01). Conclusions: The MKP-1 expression in HCC was an independent prognostic factor for outcome in HCC patients. In the future, it will be useful to explore whether the phosphatase expression might account for the response to HCC treatments targeting at MARK activation.

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