Suppression of band broadening in monodispersed and polydispersed micropillar array columns in liquid chromatography

T. Iwaba, T. Naito, T. Kubo, K. Otsuka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Suppression of band broadening in liquid chromatography is important to improve column efficiency. We investigate a mechanism of band broadening in the monodispersed and polydispersed microstructured-columns. The bed porosity and pillar size distribution were controlled in these columns by using microfabrication techniques. The decrease of the bed porosity increased the A term in the Knox plot. The polydispersed pillar columns decreased the B and C terms. These results suggested that the decrease of stagnation in microchannel caused the suppression of band broadening.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages1426-1427
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Externally publishedYes
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Publication series

Name20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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