Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients

Keiko Miura, Kiyoshi Matsumura, Yoshito Nakamura, Hideo Kurokawa, Minoru Kajiyama, Yutaka Takata

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We determined the changes in blood pressure, pulse rate, and heart rate variability during dental surgery in hypertensive patients. The study included 18 essential hypertensives and 18 age and sex matched normotensive controls who underwent tooth extraction at our hospital. Holter electrocardiographic monitoring was used to determine the power spectrum of R-R variability before and during dental surgery. The low frequency (LF: 0.041 to 0.140 Hz), high frequency (HF: 0.140 to 0.500 Hz), and total spectral powers (TF: 0.000 to 4.000 Hz) were calculated, and the ratio of LF to HF and the percentage of HF relative to TF (%HF: HF/TF x 100) were used as indexes of sympathetic and parasympathetic activities, respectively. The baseline blood pressure for hypertensive patients (149 ± 4/85 ± 2 mmHg) was significantly higher than that for normotensive patients (119 ± 3/71 ± 2 mmHg). The baseline pulse rates were similar between the two groups. Blood pressure increased during tooth extraction in both groups; however, changes in blood pressure did not differ between them. Administration of local anesthetic significantly decreased the %HF in normotensive patients (before vs. after anesthesia; 22.3 ± 2.4 vs. 13.8 ± 2.7%, p < 0.05). In contrast, the LF/HF significantly decreased during the local anesthesia and tooth extraction in hypertensive patients. These results suggest that presser response induced by tooth extraction did not differ between normotensive and hypertensive patients, and that suppression of the cardiac sympathetic nervous system during dental surgery might attenuate the pressor response in patients with hypertension.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalHypertension Research
Volume23
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

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Sympathetic Nervous System
Tooth
Tooth Extraction
Blood Pressure
Heart Rate
Ambulatory Electrocardiography
Local Anesthesia
Local Anesthetics
Anesthesia
Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Miura, K., Matsumura, K., Nakamura, Y., Kurokawa, H., Kajiyama, M., & Takata, Y. (2000). Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients. Hypertension Research, 23(3), 207-212. https://doi.org/10.1291/hypres.23.207

Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients. / Miura, Keiko; Matsumura, Kiyoshi; Nakamura, Yoshito; Kurokawa, Hideo; Kajiyama, Minoru; Takata, Yutaka.

In: Hypertension Research, Vol. 23, No. 3, 01.01.2000, p. 207-212.

Research output: Contribution to journalArticle

Miura, K, Matsumura, K, Nakamura, Y, Kurokawa, H, Kajiyama, M & Takata, Y 2000, 'Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients', Hypertension Research, vol. 23, no. 3, pp. 207-212. https://doi.org/10.1291/hypres.23.207
Miura, Keiko ; Matsumura, Kiyoshi ; Nakamura, Yoshito ; Kurokawa, Hideo ; Kajiyama, Minoru ; Takata, Yutaka. / Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients. In: Hypertension Research. 2000 ; Vol. 23, No. 3. pp. 207-212.
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