TY - JOUR
T1 - Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality.
AU - Kurashige, Junji
AU - Sawada, Genta
AU - Takahashi, Yusuke
AU - Eguchi, Hidetoshi
AU - Sudo, Tomoya
AU - Ikegami, Toru
AU - Yoshizumi, Tomoharu
AU - Soejima, Yuji
AU - Ikeda, Tetsuo
AU - Kawanaka, Hirofumi
AU - Uchiyama, Hideaki
AU - Yamashita, Yo Ichi
AU - Morita, Masaru
AU - Oki, Eiji
AU - Saeki, Hiroshi
AU - Sugimachi, Keishi
AU - Watanabe, Masayuki
AU - Mori, Masaki
AU - Baba, Hideo
AU - Mimori, Koshi
PY - 2013/10
Y1 - 2013/10
N2 - The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer. The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors. In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05). The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.
AB - The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer. The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors. In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05). The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.
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M3 - Article
C2 - 24511665
AN - SCOPUS:84897570945
SN - 1040-6182
VL - 104
SP - 344
EP - 349
JO - Quaternary International
JF - Quaternary International
IS - 10
ER -
