Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality.

Junji Kurashige, Genta Sawada, Yusuke Takahashi, Hidetoshi Eguchi, Tomoya Sudo, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Hirofumi Kawanaka, Hideaki Uchiyama, Yo Ichi Yamashita, Masaru Morita, Eiji Oki, Hiroshi Saeki, Keishi Sugimachi, Masayuki Watanabe, Masaki Mori, Hideo Baba, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer. The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors. In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05). The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalUnknown Journal
Volume104
Issue number10
Publication statusPublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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