Suppression of the phytohemagglutinin response to lymphocytes is an independent prognosticator in patients with squamous cell carcinoma of the esophagus

Tadahiro Nozoe, Daisuke Korenaga, Takefumi Ohga, Motonori Futatsugi, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background. The preoperative immunological condition of patients with malignant tumors should be considered in determining the prognosis. Methods. A lymphoblastic transformation test in which lymphocytes were stimulated with phytohemagglutinin (PHA) was performed for 155 patients with esophageal squamous cell carcinoma (SCC). Results. Multivariate analysis demonstrated that a lower preoperative PHA response (p = 0.028), as well as the depth of the tumor (p = 0.011), lymph node metastasis (p = 0.0003), lymphatic permeation (p = 0.002), and the incidence of postoperative complication (p = 0.016) were independent factors associated with a poor prognosis for patients with SCC of the esophagus. Conclusions. A suppressed PHA response is an additional significant prognosticator for SCC of the esophagus.

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalAnnals of Thoracic Surgery
Volume76
Issue number1
DOIs
Publication statusPublished - Jul 1 2003

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Surgery

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