Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus

Yupin Li, Takeki Hamasaki, Noboru Nakamichi, Taichi Kashiwagi, Takaaki Komatsu, Jun Ye, Kiichiro Teruya, Masumi Abe, Hanxu Yan, Tomoya Kinjo, Shigeru Kabayama, Munenori Kawamura, Sanetaka Shirahata

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23 Citations (Scopus)

Abstract

Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. Here, we showed that electrolyzed reduced water prevented alloxan-induced DNA fragmentation and the production of cells in sub-G1 phase in HIT-T15 pancreatic β-cells. Blood glucose levels in alloxan-induced type 1 diabetes model mice were also significantly suppressed by feeding the mice with electrolyzed reduced water. These results suggest that electrolyzed reduced water can prevent apoptosis of pancreatic β-cells and the development of symptoms in type 1 diabetes model mice by alleviating the alloxan-derived generation of reactive oxygen species.

Original languageEnglish
Pages (from-to)119-131
Number of pages13
JournalCytotechnology
Volume63
Issue number2
DOIs
Publication statusPublished - Mar 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

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  • Cite this

    Li, Y., Hamasaki, T., Nakamichi, N., Kashiwagi, T., Komatsu, T., Ye, J., Teruya, K., Abe, M., Yan, H., Kinjo, T., Kabayama, S., Kawamura, M., & Shirahata, S. (2011). Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 63(2), 119-131. https://doi.org/10.1007/s10616-010-9317-6