Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Hirofumi Noguchi, Jesse Garcia Castillo, Kinichi Nakashima, Samuel J. Pleasure

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Adult hippocampal neurogenesis requires the quiescent neural stem cell (NSC) pool to persist lifelong. However, establishment and maintenance of quiescent NSC pools during development is not understood. Here, we show that Suppressor of Fused (Sufu) controls establishment of the quiescent NSC pool during mouse dentate gyrus (DG) development by regulating Sonic Hedgehog (Shh) signaling activity. Deletion of Sufu in NSCs early in DG development decreases Shh signaling activity leading to reduced proliferation of NSCs, resulting in a small quiescent NSC pool in adult mice. We found that putative adult NSCs proliferate and increase their numbers in the first postnatal week and subsequently enter a quiescent state towards the end of the first postnatal week. In the absence of Sufu, postnatal expansion of NSCs is compromised, and NSCs prematurely become quiescent. Thus, Sufu is required for Shh signaling activity ensuring expansion and proper transition of NSC pools to quiescent states during DG development.

Original languageEnglish
JournaleLife
Volume8
DOIs
Publication statusPublished - Apr 11 2019

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Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
Neurogenesis
Maintenance

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells. / Noguchi, Hirofumi; Castillo, Jesse Garcia; Nakashima, Kinichi; Pleasure, Samuel J.

In: eLife, Vol. 8, 11.04.2019.

Research output: Contribution to journalArticle

Noguchi, Hirofumi ; Castillo, Jesse Garcia ; Nakashima, Kinichi ; Pleasure, Samuel J. / Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells. In: eLife. 2019 ; Vol. 8.
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