TY - JOUR
T1 - Suppressor of Hairless, the Drosophila homologue of RBP-Jϰ, transactivates the neurogenic gene E(spl)m8
AU - Furukawa, Takahisa
AU - Tamura, Kumiko
AU - Kawaichi, Masashi
AU - Honjo, Tasuku
AU - Kobayakawa, Yoshitaka
AU - Tanimura, Teiichi
AU - Kimura, Ken ichi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Suppressor of Hairless[Su(H)], the Drosophila homologue of RBP-J x is a novel type of sequence-specific DNA binding protein without known motifs, and highly conserved in various organisms. Su(H) regulates peripheral nervous system (PNS) development. Recently Su(H) was suggested to participate in the Notch-mediated signal transduction pathway. We show here that the Su(H) protein binds to TGTGGGAA sequence located 616 base-pairs upstream of the transcription initiation site of the Enhancer of split [E(spl)]m8 gene which is mapped to the terminus of the genetic cascade of the neurogenic genes. Su(H) transactivates the E(spl)m8 promoter not only in cultured Drosophila cells but also in vivo. The present study bridges the biochemical gap between Notch and E(spl) in the neurogenic gene cascade including Delta, Notch, deltex, Su(H), Hairless and E(spl).
AB - Suppressor of Hairless[Su(H)], the Drosophila homologue of RBP-J x is a novel type of sequence-specific DNA binding protein without known motifs, and highly conserved in various organisms. Su(H) regulates peripheral nervous system (PNS) development. Recently Su(H) was suggested to participate in the Notch-mediated signal transduction pathway. We show here that the Su(H) protein binds to TGTGGGAA sequence located 616 base-pairs upstream of the transcription initiation site of the Enhancer of split [E(spl)]m8 gene which is mapped to the terminus of the genetic cascade of the neurogenic genes. Su(H) transactivates the E(spl)m8 promoter not only in cultured Drosophila cells but also in vivo. The present study bridges the biochemical gap between Notch and E(spl) in the neurogenic gene cascade including Delta, Notch, deltex, Su(H), Hairless and E(spl).
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U2 - 10.1266/jjg.70.505
DO - 10.1266/jjg.70.505
M3 - Article
C2 - 7546844
AN - SCOPUS:0029076059
SN - 1341-7568
VL - 70
SP - 505
EP - 524
JO - Genes and Genetic Systems
JF - Genes and Genetic Systems
IS - 4
ER -