Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man

Yasuharu Nishimura, Takehiko Sasazuki

Research output: Contribution to journalLetter

43 Citations (Scopus)

Abstract

We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function1. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness2. Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalNature
Volume302
Issue number5903
DOIs
Publication statusPublished - Dec 1 1983
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • General

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