Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man

Yasuharu Nishimura; Takehiko Sasazuki

doi:10.1038/302067a0

Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man

Yasuharu Nishimura, Takehiko Sasazuki

Research output: Contribution to journal › Letter › peer-review

43 Citations (Scopus)

Abstract

We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function¹. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness². Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.

Original language	English
Pages (from-to)	67-69
Number of pages	3
Journal	Nature
Volume	302
Issue number	5903
DOIs	https://doi.org/10.1038/302067a0
Publication status	Published - Dec 1 1983
Externally published	Yes

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title = "Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man",

abstract = "We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function1. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness2. Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.",

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AU - Sasazuki, Takehiko

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N2 - We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function1. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness2. Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.

AB - We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function1. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness2. Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.

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Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man

Abstract

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