Supramolecular architectures toward biological applications

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Biological supramolecular assemblies, as exemplified by nucleic acid multiplexes, multimeric proteins, nucleic acid-protein complexes and viruses provide a variety of soluble superstructures in the mesoscopic range (ca. 10 to 1000 nm in scale). They spontaneously self-assemble in aqueous media by ingeniously employing multiple noncovalent interactions such as electrostatic interactions, hydrogen bonding, dipole-dipole interactions, and hydrophobic association. Figure 18.1 illustrates the hierarchy of molecular assemblies in biological and synthetic systems. Amino acids are arranged into peptides and proteins that fold into nanostructures. These units may further assemble into mesoscopic structures, such as the tobacco mosaic virus, actin fibers, or microtubules 2.

Original languageEnglish
Title of host publicationSupramolecular Design for Biological Applications
PublisherCRC Press
Pages373-396
Number of pages24
ISBN (Electronic)9781420041187
ISBN (Print)9780849309656
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)

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