Supramolecular hydrogel exhibiting four basic logic gate functions to fine-tune substance release

Harunobu Komatsu, Shinji Matsumoto, Shun ichi Tamaru, Kenji Kaneko, Masato Ikeda, Itaru Hamachi

Research output: Contribution to journalArticle

247 Citations (Scopus)

Abstract

Logic-gate operations displaying macroscopic outputs are promising systems for the development of intelligent soft materials that can perform effective functions in response to various input patterns. A supramolecular hydrogel comprising the phosphate-type hydrogelator 1 exhibits macroscopic gel - sol behavior in response to four distinct input stimuli: temperature, pH, Ca 2+, and light. We characterized this performance through microscopic, spectroscopic, and rheological measurements. On the basis of its multiplestimulus responsiveness, we constructed gel-based supramolecular logic gates from hydrogelator 1 that demonstrated AND, OR, NAND, and NOR types of stimulus-responsive gel-sol behavior in the presence of various combinations of the four stimuli. Implementation of such logic-gate functions into semiwet soft materials (e.g., supramolecular hydrogels) is an important step toward the design of controlled drug delivery and release systems. Indeed, we demonstrate herein that one of our gel-based supramolecular logic gates is capable of holding and releasing bioactive substances in response to logic triggers. Furthermore, combining our supramolecular gel-based AND logic gate with a photoresponsive supramolecular gel could temporarily modulate the release rate of the bioactive substance.

Original languageEnglish
Pages (from-to)5580-5585
Number of pages6
JournalJournal of the American Chemical Society
Volume131
Issue number15
DOIs
Publication statusPublished - Apr 22 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Supramolecular hydrogel exhibiting four basic logic gate functions to fine-tune substance release'. Together they form a unique fingerprint.

  • Cite this