TY - JOUR
T1 - Surface expression of gabaA receptors
T2 - Roles for the binding partners
AU - Kanematsu, Takashi
AU - Fujii, Makoto
AU - Tanaka, Hiroto
AU - Umebayashi, Hisanori
AU - Hirata, Masato
N1 - Funding Information:
The work performed in our laboratory is supported by the following grants:a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan(TK, MF and MH), the Cooperative Study Program of the National Institute for Physiological Sciences (TK and MH), and the Pharmacological Research Foundation, Tokyo (to TK). MF is a Research Fellow supported by the Japan Society for the Promotion of Science.
PY - 2010
Y1 - 2010
N2 - The transmission of sensory information to the central nervous system during oral functions such as mastication and swallowing is well regulated by neural networks, including 7gamma;-aminobutyric acid (GABA)-mediated inhibitory interneurons. Therefore, an understanding of the mechanism of GABAergic transmission might provide new insight into theclinical treatment of eating and swallowing disorders. Type A GABA receptors are ligand-gated Cl- channels composed pentamerically of two a(1-6), two y3(1-3), and one γ(1-3) subunit. One major issue regarding the efficacy of GABAergic transmissionis how to control receptor numbers on neuronal surfaces, determining synaptic strength. The number of receptors on the postsynaptic membrane is maintained by a balance between receptor insertion and endocytosis. Insulin increases the number of GABAA receptors by stimulating insertion into the surface membrane via Akt-mediated phosphorylation of the subunits. Conversely, brain-derived neurotrophic factor decreases the number by stimulating endocytosis. Here we show that PRIP (phospholipase C-related but catalytically inactive protein), isolated in our laboratory, actively participates in these two events by regulating the phosphorylation of/J subunits and controlling the functions of binding partners such as Akt and protein phosphatases.
AB - The transmission of sensory information to the central nervous system during oral functions such as mastication and swallowing is well regulated by neural networks, including 7gamma;-aminobutyric acid (GABA)-mediated inhibitory interneurons. Therefore, an understanding of the mechanism of GABAergic transmission might provide new insight into theclinical treatment of eating and swallowing disorders. Type A GABA receptors are ligand-gated Cl- channels composed pentamerically of two a(1-6), two y3(1-3), and one γ(1-3) subunit. One major issue regarding the efficacy of GABAergic transmissionis how to control receptor numbers on neuronal surfaces, determining synaptic strength. The number of receptors on the postsynaptic membrane is maintained by a balance between receptor insertion and endocytosis. Insulin increases the number of GABAA receptors by stimulating insertion into the surface membrane via Akt-mediated phosphorylation of the subunits. Conversely, brain-derived neurotrophic factor decreases the number by stimulating endocytosis. Here we show that PRIP (phospholipase C-related but catalytically inactive protein), isolated in our laboratory, actively participates in these two events by regulating the phosphorylation of/J subunits and controlling the functions of binding partners such as Akt and protein phosphatases.
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U2 - 10.2330/joralbiosci.52.322
DO - 10.2330/joralbiosci.52.322
M3 - Article
AN - SCOPUS:79952237063
VL - 52
SP - 322
EP - 329
JO - Journal of Oral Biosciences
JF - Journal of Oral Biosciences
SN - 1349-0079
IS - 4
ER -