Surface reactivity of octacalcium phosphate-derived fluoride-containing apatite in the presence of polyols and fluoride

Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Hajime Yamazaki, Osamu Suzuki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The present study was designed to characterize co-precipitated fluoridated apatitic materials from octacalcium phosphate (OCP) precursor and to investigate their surface reactions with polyols including glycerol in the presence of fluoride ions. Laboratory-synthesized fluoridated apatite crystals (LS-FA) were obtained in a solution containing fluoride (F) from 25 to 500 ppm. LS-FAs and commercially available fluoroapatite (FA) and hydroxyapatite (HA) were characterized by physical techniques, such as X-ray diffraction. LS-FA obtained in the presence of 100 ppmF (100 ppm-LS-FA) had an apatitic structure, but its solubility was close to HA in a culture medium (α-MEM) despite the fact it contains over 3 wt % of F. 100 ppm-LS-FA, FA, and HA were then subjected to the human serum albumin (HSA) adsorption test at pH 7.4 (in a 150 mM Tris–HCl buffer) and the dissolution and re-mineralization experiments in the presence of xylitol, D-sorbitol, or glycerol, and F under acidic and neutral conditions. Adsorption affinity of HSA was estimated as highest for FA and lowest for LS-FA. LS-FA, FA, and HA were immersed in a lactic acid solution with the polyols and/or F ion-containing solution up to 200 ppm to analyze the dissolution behavior. LS-FA had the highest dissolution tendency in the conditions examined. Glycerol enhanced the dissolution of phosphate from apatite crystals in particular from LS-FA. The results suggest that the apatite crystals, obtained through the hydrolysis of OCP in the presence of F, provide a more reactive surface than FA or HA under physiological environments.

Original languageEnglish
Pages (from-to)2235-2244
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume106
Issue number6
DOIs
Publication statusPublished - Aug 1 2018
Externally publishedYes

Fingerprint

Apatites
Polyols
Apatite
Fluorides
Phosphates
Crystals
Durapatite
Hydroxyapatite
Dissolution
Glycerol
Serum Albumin
polyol
octacalcium phosphate
Ions
Xylitol
Adsorption
Sorbitol
Surface reactions
Lactic acid
Culture Media

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Surface reactivity of octacalcium phosphate-derived fluoride-containing apatite in the presence of polyols and fluoride. / Tsutsui, Sei; Anada, Takahisa; Shiwaku, Yukari; Tsuchiya, Kaori; Yamazaki, Hajime; Suzuki, Osamu.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 106, No. 6, 01.08.2018, p. 2235-2244.

Research output: Contribution to journalArticle

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AB - The present study was designed to characterize co-precipitated fluoridated apatitic materials from octacalcium phosphate (OCP) precursor and to investigate their surface reactions with polyols including glycerol in the presence of fluoride ions. Laboratory-synthesized fluoridated apatite crystals (LS-FA) were obtained in a solution containing fluoride (F) from 25 to 500 ppm. LS-FAs and commercially available fluoroapatite (FA) and hydroxyapatite (HA) were characterized by physical techniques, such as X-ray diffraction. LS-FA obtained in the presence of 100 ppmF (100 ppm-LS-FA) had an apatitic structure, but its solubility was close to HA in a culture medium (α-MEM) despite the fact it contains over 3 wt % of F. 100 ppm-LS-FA, FA, and HA were then subjected to the human serum albumin (HSA) adsorption test at pH 7.4 (in a 150 mM Tris–HCl buffer) and the dissolution and re-mineralization experiments in the presence of xylitol, D-sorbitol, or glycerol, and F under acidic and neutral conditions. Adsorption affinity of HSA was estimated as highest for FA and lowest for LS-FA. LS-FA, FA, and HA were immersed in a lactic acid solution with the polyols and/or F ion-containing solution up to 200 ppm to analyze the dissolution behavior. LS-FA had the highest dissolution tendency in the conditions examined. Glycerol enhanced the dissolution of phosphate from apatite crystals in particular from LS-FA. The results suggest that the apatite crystals, obtained through the hydrolysis of OCP in the presence of F, provide a more reactive surface than FA or HA under physiological environments.

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