Surgery for small cell lung cancer

A retrospective analysis of 243 patients from japanese lung cancer registry in 2004

Hidefumi Takei, Haruhiko Kondo, Etsuo Miyaoka, Hisao Asamura, Ichiro Yoshino, Hiroshi Date, Meinoshin Okumura, Hirohito Tada, Yoshitaka Fujii, Yoichi Nakanishi, Kenji Eguchi, Hirotoshi Dosaka-Akita, Hideo Kobayashi, Noriyoshi Sawabata, Kohei Yokoi

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Abstract

Introduction: Indications for surgical resection for small cell lung cancer (SCLC) have been very limited. Because early-stage SCLC is a rare presentation of lung cancer, studies comparing surgical resection among a large number of patients are unlikely to be conducted. This study reports the most recent surgical outcomes of a large number of SCLC patients who underwent surgery in 2004.Methods: In 2010, the Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study regarding the prognosis and clinicopathologic profiles of 11,663 patients who underwent resection for primary lung cancer in 2004. Of the 11,663 patients, 243 patients with SCLC (2.1%) were included in this study. The registry data of the patients with SCLC were analyzed, and the clinicopathologic profiles and surgical outcomes of the patients were evaluated.Results: The 5-year survival rate for all cases (n = 243, 213 males, mean age 68.2 years) was 52.6%. The 5-year survival rates by c-stage and p-stage were as follows: IA, 64.3% (n = 132) and 72.3% (n = 93); IB, 45.7% (n = 36) and 61.1% (n = 51); IIA, 50.5% (n =25); and 44.8% (n = 27); IIB, 33.3% (n = 10) and 40.3% (n = 17); IIIA, 30.5% (n = 30) and 23.4% (n = 45); and IV, 0% (n = 7) and 0% (n = 9), respectively. A multivariate analysis showed that the significant prognostic factors were age, gender, c-stage, and surgical curability. A kappa value was moderate conformity between c-stage and p-stage in all cases.Conclusions: Surgical resection in selected patients with early-stage SCLC, especially stage I, had favorable results.

Original languageEnglish
Pages (from-to)1140-1145
Number of pages6
JournalJournal of Thoracic Oncology
Volume9
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

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Small Cell Lung Carcinoma
Registries
Lung Neoplasms
Survival Rate
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

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Surgery for small cell lung cancer : A retrospective analysis of 243 patients from japanese lung cancer registry in 2004. / Takei, Hidefumi; Kondo, Haruhiko; Miyaoka, Etsuo; Asamura, Hisao; Yoshino, Ichiro; Date, Hiroshi; Okumura, Meinoshin; Tada, Hirohito; Fujii, Yoshitaka; Nakanishi, Yoichi; Eguchi, Kenji; Dosaka-Akita, Hirotoshi; Kobayashi, Hideo; Sawabata, Noriyoshi; Yokoi, Kohei.

In: Journal of Thoracic Oncology, Vol. 9, No. 8, 01.01.2014, p. 1140-1145.

Research output: Contribution to journalArticle

Takei, H, Kondo, H, Miyaoka, E, Asamura, H, Yoshino, I, Date, H, Okumura, M, Tada, H, Fujii, Y, Nakanishi, Y, Eguchi, K, Dosaka-Akita, H, Kobayashi, H, Sawabata, N & Yokoi, K 2014, 'Surgery for small cell lung cancer: A retrospective analysis of 243 patients from japanese lung cancer registry in 2004', Journal of Thoracic Oncology, vol. 9, no. 8, pp. 1140-1145. https://doi.org/10.1097/JTO.0000000000000226
Takei, Hidefumi ; Kondo, Haruhiko ; Miyaoka, Etsuo ; Asamura, Hisao ; Yoshino, Ichiro ; Date, Hiroshi ; Okumura, Meinoshin ; Tada, Hirohito ; Fujii, Yoshitaka ; Nakanishi, Yoichi ; Eguchi, Kenji ; Dosaka-Akita, Hirotoshi ; Kobayashi, Hideo ; Sawabata, Noriyoshi ; Yokoi, Kohei. / Surgery for small cell lung cancer : A retrospective analysis of 243 patients from japanese lung cancer registry in 2004. In: Journal of Thoracic Oncology. 2014 ; Vol. 9, No. 8. pp. 1140-1145.
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abstract = "Introduction: Indications for surgical resection for small cell lung cancer (SCLC) have been very limited. Because early-stage SCLC is a rare presentation of lung cancer, studies comparing surgical resection among a large number of patients are unlikely to be conducted. This study reports the most recent surgical outcomes of a large number of SCLC patients who underwent surgery in 2004.Methods: In 2010, the Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study regarding the prognosis and clinicopathologic profiles of 11,663 patients who underwent resection for primary lung cancer in 2004. Of the 11,663 patients, 243 patients with SCLC (2.1{\%}) were included in this study. The registry data of the patients with SCLC were analyzed, and the clinicopathologic profiles and surgical outcomes of the patients were evaluated.Results: The 5-year survival rate for all cases (n = 243, 213 males, mean age 68.2 years) was 52.6{\%}. The 5-year survival rates by c-stage and p-stage were as follows: IA, 64.3{\%} (n = 132) and 72.3{\%} (n = 93); IB, 45.7{\%} (n = 36) and 61.1{\%} (n = 51); IIA, 50.5{\%} (n =25); and 44.8{\%} (n = 27); IIB, 33.3{\%} (n = 10) and 40.3{\%} (n = 17); IIIA, 30.5{\%} (n = 30) and 23.4{\%} (n = 45); and IV, 0{\%} (n = 7) and 0{\%} (n = 9), respectively. A multivariate analysis showed that the significant prognostic factors were age, gender, c-stage, and surgical curability. A kappa value was moderate conformity between c-stage and p-stage in all cases.Conclusions: Surgical resection in selected patients with early-stage SCLC, especially stage I, had favorable results.",
author = "Hidefumi Takei and Haruhiko Kondo and Etsuo Miyaoka and Hisao Asamura and Ichiro Yoshino and Hiroshi Date and Meinoshin Okumura and Hirohito Tada and Yoshitaka Fujii and Yoichi Nakanishi and Kenji Eguchi and Hirotoshi Dosaka-Akita and Hideo Kobayashi and Noriyoshi Sawabata and Kohei Yokoi",
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T2 - A retrospective analysis of 243 patients from japanese lung cancer registry in 2004

AU - Takei, Hidefumi

AU - Kondo, Haruhiko

AU - Miyaoka, Etsuo

AU - Asamura, Hisao

AU - Yoshino, Ichiro

AU - Date, Hiroshi

AU - Okumura, Meinoshin

AU - Tada, Hirohito

AU - Fujii, Yoshitaka

AU - Nakanishi, Yoichi

AU - Eguchi, Kenji

AU - Dosaka-Akita, Hirotoshi

AU - Kobayashi, Hideo

AU - Sawabata, Noriyoshi

AU - Yokoi, Kohei

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N2 - Introduction: Indications for surgical resection for small cell lung cancer (SCLC) have been very limited. Because early-stage SCLC is a rare presentation of lung cancer, studies comparing surgical resection among a large number of patients are unlikely to be conducted. This study reports the most recent surgical outcomes of a large number of SCLC patients who underwent surgery in 2004.Methods: In 2010, the Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study regarding the prognosis and clinicopathologic profiles of 11,663 patients who underwent resection for primary lung cancer in 2004. Of the 11,663 patients, 243 patients with SCLC (2.1%) were included in this study. The registry data of the patients with SCLC were analyzed, and the clinicopathologic profiles and surgical outcomes of the patients were evaluated.Results: The 5-year survival rate for all cases (n = 243, 213 males, mean age 68.2 years) was 52.6%. The 5-year survival rates by c-stage and p-stage were as follows: IA, 64.3% (n = 132) and 72.3% (n = 93); IB, 45.7% (n = 36) and 61.1% (n = 51); IIA, 50.5% (n =25); and 44.8% (n = 27); IIB, 33.3% (n = 10) and 40.3% (n = 17); IIIA, 30.5% (n = 30) and 23.4% (n = 45); and IV, 0% (n = 7) and 0% (n = 9), respectively. A multivariate analysis showed that the significant prognostic factors were age, gender, c-stage, and surgical curability. A kappa value was moderate conformity between c-stage and p-stage in all cases.Conclusions: Surgical resection in selected patients with early-stage SCLC, especially stage I, had favorable results.

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