Surgical complications after living donor liver transplantation in patients with biliary atresia: A relatively high incidence of portal vein complications

Yukiko Takahashi, Yuko Nishimoto, Toshiharu Matsuura, Makoto Hayashida, Tatsuro Tajiri, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara, Tomoaki Taguchi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background/purpose: The aim of this study is to present the surgical complications in living donor liver transplantation (LDLT) for biliary atresia (BA) as a treatment for end stage liver disease. Patients and methods: Twenty-nine LDLTs were performed in patients with BA between October 1996 and April 2008 in Department of Pediatric Surgery at Kyushu University Hospital. The initial immunosuppression was a combination of tacrolimus and steroids. Results: Twenty-eight of 29 cases with BA, who previously underwent Kasai's operation and LDLT was performed at a median age of 9.1 years (range 7 months to 28 years). Only one case was performed primary LDLT. Post-transplant complications included portal vein complications (n = 5), three of which successfully treated by Rex-shunt or ballooning. Others were bile leakage (n = 4), intestinal perforation (n = 4), and so on. The overall survival rate was 86.2% (25/29). One patient died of chronic rejection, surgical complications after LDLT in BA while others died of sepsis, multi-organ failure, and brain hemorrhage. Conclusion: The incidence of portal vein complications and intestinal perforations was relatively high in LDLT for BA, possibly due to inflammation of the hepatoduodenal ligament and colonic adhesion to the liver. It is important to make an accurate diagnosis at an early stage and provide appropriate treatment.

Original languageEnglish
Pages (from-to)745-751
Number of pages7
JournalPediatric surgery international
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2009

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Fingerprint Dive into the research topics of 'Surgical complications after living donor liver transplantation in patients with biliary atresia: A relatively high incidence of portal vein complications'. Together they form a unique fingerprint.

  • Cite this