Surgical outcomes of anatomical resection for solitary recurrent hepatocellular carcinoma

Yo Ichi Yamashita, Daisuke Imai, Yuki Bekki, Kazuki Takeishi, Eiji Tsujita, Toru Ikegami, Tomoharu Yoshizumi, Tetsuo Ikeda, Ken Shirabe, Teruyoshi Ishida, Yoshihiko Maehara

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Abstract

Background: For eradicating portal venous tumor extension and intrahepatic metastasis in hepatocellular carcinoma (HCC), anatomical resection is, in theory, preferable. Patients and Methods: We carried-out a retrospective cohort study in 110 patients who underwent curative hepatic resection (anatomical resection; n=20, and limited resection; n=90) for solitary recurrent HCC from 1990-2010. Results: No significant difference was found in short-term surgical results such as mortality, morbidity, and duration of hospital stay between the two groups. Anatomical resection did not influence overall and disease-free survival for all patients with a solitary recurrent HCC. In patients with cancer spread, such as pathological vascular invasion and intrahepatic metastasis (n=61), or with des-ã-carboxy prothrombin (DCP)≥100 mAU/ml (n=73), the disease-free survival rate in the anatomical-resection group was significantly better than that in the limited-resection group (p=0.0452 and p=0.0345, respectively). Conclusion: Anatomical resection should be recommended only for HCC suspected of exhibiting cancer spread as reflected by DCP ≥100 mAU/ml in patients with solitary recurrent HCC.

Original languageEnglish
Pages (from-to)4421-4426
Number of pages6
JournalAnticancer research
Volume34
Issue number8
Publication statusPublished - Aug 1 2014

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yamashita, Y. I., Imai, D., Bekki, Y., Takeishi, K., Tsujita, E., Ikegami, T., ... Maehara, Y. (2014). Surgical outcomes of anatomical resection for solitary recurrent hepatocellular carcinoma. Anticancer research, 34(8), 4421-4426.