Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: What is the impact of Parkinson's disease on surgical outcome?

Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka YoshiiShuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of fusion surgery for patients with Parkinson's disease (PD) with osteoporotic vertebral fracture (OVF) in the thoracolumbar junction. Methods: Retrospectively registered data were collected from 27 universities and their affiliated hospitals in Japan. In total, 26 patients with PD (mean age, 76 years; 3 men and 23 women) with thoracolumbar OVF who underwent spinal fusion with a minimum of 2 years of follow-up were included (PD group). Surgical invasion, perioperative complications, radiographic sagittal alignment, mechanical failure (MF) related to instrumentation, and clinical outcomes were evaluated. A control group of 296 non-PD patients (non-PD group) matched for age, sex, distribution of surgical procedures, number of fused segments, and follow-up period were used for comparison. Results: The PD group showed higher rates of perioperative complications (p < 0.01) and frequency of delirium than the non-PD group (p < 0.01). There were no significant differences in the degree of kyphosis correction, frequency of MF, visual analog scale of the symptoms, and improvement according to the Japanese Orthopaedic Association scoring system between the two groups. However, the PD group showed a higher proportion of non-ambulators and dependent ambulators with walkers at the final follow-up (p < 0.01). Conclusions: A similar surgical strategy can be applicable to patients with PD with OVF in the thoracolumbar junction. However, physicians should pay extra attention to intensive perioperative care to prevent various adverse events and implement a rehabilitation regimen to regain walking ability.

Original languageEnglish
Article number103
JournalBMC Musculoskeletal Disorders
Volume20
Issue number1
DOIs
Publication statusPublished - Mar 9 2019

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Spinal Fusion
Parkinson Disease
Osteoporotic Fractures
Walkers
Perioperative Care
Kyphosis
Sex Distribution
Aptitude
Delirium
Age Distribution
Critical Care
Visual Analog Scale
Multicenter Studies
Walking
Registries
Japan
Research Design
Rehabilitation
Retrospective Studies
Physicians

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Orthopedics and Sports Medicine

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Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease : What is the impact of Parkinson's disease on surgical outcome? / Watanabe, Kei; Katsumi, Keiichi; Ohashi, Masayuki; Shibuya, Yohei; Izumi, Tomohiro; Hirano, Toru; Endo, Naoto; Kaito, Takashi; Yamashita, Tomoya; Fujiwara, Hiroyasu; Nagamoto, Yukitaka; Matsuoka, Yuji; Suzuki, Hidekazu; Nishimura, Hirosuke; Terai, Hidetomi; Tamai, Koji; Tagami, Atsushi; Yamada, Syuta; Adachi, Shinji; Yoshii, Toshitaka; Ushio, Shuta; Harimaya, Katsumi; Kawaguchi, Kenichi; Yokoyama, Nobuhiko; Oishi, Hidekazu; Doi, Toshiro; Kimura, Atsushi; Inoue, Hirokazu; Inoue, Gen; Miyagi, Masayuki; Saito, Wataru; Nakano, Atsushi; Sakai, Daisuke; Nukaga, Tadashi; Ikegami, Shota; Shimizu, Masayuki; Futatsugi, Toshimasa; Ohtori, Seiji; Furuya, Takeo; Orita, Sumihisa; Imagama, Shiro; Ando, Kei; Kobayashi, Kazuyoshi; Kiyasu, Katsuhito; Murakami, Hideki; Yoshioka, Katsuhito; Seki, Shoji; Hongo, Michio; Kakutani, Kenichiro; Yurube, Takashi; Aoki, Yasuchika; Oshima, Masashi; Takahata, Masahiko; Iwata, Akira; Endo, Hirooki; Abe, Tetsuya; Tsukanishi, Toshinori; Nakanishi, Kazuyoshi; Watanabe, Kota; Hikata, Tomohiro; Suzuki, Satoshi; Isogai, Norihiro; Okada, Eijiro; Funao, Haruki; Ueda, Seiji; Shiono, Yuta; Nojiri, Kenya; Hosogane, Naobumi; Ishii, Ken.

In: BMC Musculoskeletal Disorders, Vol. 20, No. 1, 103, 09.03.2019.

Research output: Contribution to journalArticle

Watanabe, K, Katsumi, K, Ohashi, M, Shibuya, Y, Izumi, T, Hirano, T, Endo, N, Kaito, T, Yamashita, T, Fujiwara, H, Nagamoto, Y, Matsuoka, Y, Suzuki, H, Nishimura, H, Terai, H, Tamai, K, Tagami, A, Yamada, S, Adachi, S, Yoshii, T, Ushio, S, Harimaya, K, Kawaguchi, K, Yokoyama, N, Oishi, H, Doi, T, Kimura, A, Inoue, H, Inoue, G, Miyagi, M, Saito, W, Nakano, A, Sakai, D, Nukaga, T, Ikegami, S, Shimizu, M, Futatsugi, T, Ohtori, S, Furuya, T, Orita, S, Imagama, S, Ando, K, Kobayashi, K, Kiyasu, K, Murakami, H, Yoshioka, K, Seki, S, Hongo, M, Kakutani, K, Yurube, T, Aoki, Y, Oshima, M, Takahata, M, Iwata, A, Endo, H, Abe, T, Tsukanishi, T, Nakanishi, K, Watanabe, K, Hikata, T, Suzuki, S, Isogai, N, Okada, E, Funao, H, Ueda, S, Shiono, Y, Nojiri, K, Hosogane, N & Ishii, K 2019, 'Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: What is the impact of Parkinson's disease on surgical outcome?', BMC Musculoskeletal Disorders, vol. 20, no. 1, 103. https://doi.org/10.1186/s12891-019-2473-8
Watanabe, Kei ; Katsumi, Keiichi ; Ohashi, Masayuki ; Shibuya, Yohei ; Izumi, Tomohiro ; Hirano, Toru ; Endo, Naoto ; Kaito, Takashi ; Yamashita, Tomoya ; Fujiwara, Hiroyasu ; Nagamoto, Yukitaka ; Matsuoka, Yuji ; Suzuki, Hidekazu ; Nishimura, Hirosuke ; Terai, Hidetomi ; Tamai, Koji ; Tagami, Atsushi ; Yamada, Syuta ; Adachi, Shinji ; Yoshii, Toshitaka ; Ushio, Shuta ; Harimaya, Katsumi ; Kawaguchi, Kenichi ; Yokoyama, Nobuhiko ; Oishi, Hidekazu ; Doi, Toshiro ; Kimura, Atsushi ; Inoue, Hirokazu ; Inoue, Gen ; Miyagi, Masayuki ; Saito, Wataru ; Nakano, Atsushi ; Sakai, Daisuke ; Nukaga, Tadashi ; Ikegami, Shota ; Shimizu, Masayuki ; Futatsugi, Toshimasa ; Ohtori, Seiji ; Furuya, Takeo ; Orita, Sumihisa ; Imagama, Shiro ; Ando, Kei ; Kobayashi, Kazuyoshi ; Kiyasu, Katsuhito ; Murakami, Hideki ; Yoshioka, Katsuhito ; Seki, Shoji ; Hongo, Michio ; Kakutani, Kenichiro ; Yurube, Takashi ; Aoki, Yasuchika ; Oshima, Masashi ; Takahata, Masahiko ; Iwata, Akira ; Endo, Hirooki ; Abe, Tetsuya ; Tsukanishi, Toshinori ; Nakanishi, Kazuyoshi ; Watanabe, Kota ; Hikata, Tomohiro ; Suzuki, Satoshi ; Isogai, Norihiro ; Okada, Eijiro ; Funao, Haruki ; Ueda, Seiji ; Shiono, Yuta ; Nojiri, Kenya ; Hosogane, Naobumi ; Ishii, Ken. / Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease : What is the impact of Parkinson's disease on surgical outcome?. In: BMC Musculoskeletal Disorders. 2019 ; Vol. 20, No. 1.
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title = "Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: What is the impact of Parkinson's disease on surgical outcome?",
abstract = "Background: To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of fusion surgery for patients with Parkinson's disease (PD) with osteoporotic vertebral fracture (OVF) in the thoracolumbar junction. Methods: Retrospectively registered data were collected from 27 universities and their affiliated hospitals in Japan. In total, 26 patients with PD (mean age, 76 years; 3 men and 23 women) with thoracolumbar OVF who underwent spinal fusion with a minimum of 2 years of follow-up were included (PD group). Surgical invasion, perioperative complications, radiographic sagittal alignment, mechanical failure (MF) related to instrumentation, and clinical outcomes were evaluated. A control group of 296 non-PD patients (non-PD group) matched for age, sex, distribution of surgical procedures, number of fused segments, and follow-up period were used for comparison. Results: The PD group showed higher rates of perioperative complications (p < 0.01) and frequency of delirium than the non-PD group (p < 0.01). There were no significant differences in the degree of kyphosis correction, frequency of MF, visual analog scale of the symptoms, and improvement according to the Japanese Orthopaedic Association scoring system between the two groups. However, the PD group showed a higher proportion of non-ambulators and dependent ambulators with walkers at the final follow-up (p < 0.01). Conclusions: A similar surgical strategy can be applicable to patients with PD with OVF in the thoracolumbar junction. However, physicians should pay extra attention to intensive perioperative care to prevent various adverse events and implement a rehabilitation regimen to regain walking ability.",
author = "Kei Watanabe and Keiichi Katsumi and Masayuki Ohashi and Yohei Shibuya and Tomohiro Izumi and Toru Hirano and Naoto Endo and Takashi Kaito and Tomoya Yamashita and Hiroyasu Fujiwara and Yukitaka Nagamoto and Yuji Matsuoka and Hidekazu Suzuki and Hirosuke Nishimura and Hidetomi Terai and Koji Tamai and Atsushi Tagami and Syuta Yamada and Shinji Adachi and Toshitaka Yoshii and Shuta Ushio and Katsumi Harimaya and Kenichi Kawaguchi and Nobuhiko Yokoyama and Hidekazu Oishi and Toshiro Doi and Atsushi Kimura and Hirokazu Inoue and Gen Inoue and Masayuki Miyagi and Wataru Saito and Atsushi Nakano and Daisuke Sakai and Tadashi Nukaga and Shota Ikegami and Masayuki Shimizu and Toshimasa Futatsugi and Seiji Ohtori and Takeo Furuya and Sumihisa Orita and Shiro Imagama and Kei Ando and Kazuyoshi Kobayashi and Katsuhito Kiyasu and Hideki Murakami and Katsuhito Yoshioka and Shoji Seki and Michio Hongo and Kenichiro Kakutani and Takashi Yurube and Yasuchika Aoki and Masashi Oshima and Masahiko Takahata and Akira Iwata and Hirooki Endo and Tetsuya Abe and Toshinori Tsukanishi and Kazuyoshi Nakanishi and Kota Watanabe and Tomohiro Hikata and Satoshi Suzuki and Norihiro Isogai and Eijiro Okada and Haruki Funao and Seiji Ueda and Yuta Shiono and Kenya Nojiri and Naobumi Hosogane and Ken Ishii",
year = "2019",
month = "3",
day = "9",
doi = "10.1186/s12891-019-2473-8",
language = "English",
volume = "20",
journal = "BMC Musculoskeletal Disorders",
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TY - JOUR

T1 - Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease

T2 - What is the impact of Parkinson's disease on surgical outcome?

AU - Watanabe, Kei

AU - Katsumi, Keiichi

AU - Ohashi, Masayuki

AU - Shibuya, Yohei

AU - Izumi, Tomohiro

AU - Hirano, Toru

AU - Endo, Naoto

AU - Kaito, Takashi

AU - Yamashita, Tomoya

AU - Fujiwara, Hiroyasu

AU - Nagamoto, Yukitaka

AU - Matsuoka, Yuji

AU - Suzuki, Hidekazu

AU - Nishimura, Hirosuke

AU - Terai, Hidetomi

AU - Tamai, Koji

AU - Tagami, Atsushi

AU - Yamada, Syuta

AU - Adachi, Shinji

AU - Yoshii, Toshitaka

AU - Ushio, Shuta

AU - Harimaya, Katsumi

AU - Kawaguchi, Kenichi

AU - Yokoyama, Nobuhiko

AU - Oishi, Hidekazu

AU - Doi, Toshiro

AU - Kimura, Atsushi

AU - Inoue, Hirokazu

AU - Inoue, Gen

AU - Miyagi, Masayuki

AU - Saito, Wataru

AU - Nakano, Atsushi

AU - Sakai, Daisuke

AU - Nukaga, Tadashi

AU - Ikegami, Shota

AU - Shimizu, Masayuki

AU - Futatsugi, Toshimasa

AU - Ohtori, Seiji

AU - Furuya, Takeo

AU - Orita, Sumihisa

AU - Imagama, Shiro

AU - Ando, Kei

AU - Kobayashi, Kazuyoshi

AU - Kiyasu, Katsuhito

AU - Murakami, Hideki

AU - Yoshioka, Katsuhito

AU - Seki, Shoji

AU - Hongo, Michio

AU - Kakutani, Kenichiro

AU - Yurube, Takashi

AU - Aoki, Yasuchika

AU - Oshima, Masashi

AU - Takahata, Masahiko

AU - Iwata, Akira

AU - Endo, Hirooki

AU - Abe, Tetsuya

AU - Tsukanishi, Toshinori

AU - Nakanishi, Kazuyoshi

AU - Watanabe, Kota

AU - Hikata, Tomohiro

AU - Suzuki, Satoshi

AU - Isogai, Norihiro

AU - Okada, Eijiro

AU - Funao, Haruki

AU - Ueda, Seiji

AU - Shiono, Yuta

AU - Nojiri, Kenya

AU - Hosogane, Naobumi

AU - Ishii, Ken

PY - 2019/3/9

Y1 - 2019/3/9

N2 - Background: To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of fusion surgery for patients with Parkinson's disease (PD) with osteoporotic vertebral fracture (OVF) in the thoracolumbar junction. Methods: Retrospectively registered data were collected from 27 universities and their affiliated hospitals in Japan. In total, 26 patients with PD (mean age, 76 years; 3 men and 23 women) with thoracolumbar OVF who underwent spinal fusion with a minimum of 2 years of follow-up were included (PD group). Surgical invasion, perioperative complications, radiographic sagittal alignment, mechanical failure (MF) related to instrumentation, and clinical outcomes were evaluated. A control group of 296 non-PD patients (non-PD group) matched for age, sex, distribution of surgical procedures, number of fused segments, and follow-up period were used for comparison. Results: The PD group showed higher rates of perioperative complications (p < 0.01) and frequency of delirium than the non-PD group (p < 0.01). There were no significant differences in the degree of kyphosis correction, frequency of MF, visual analog scale of the symptoms, and improvement according to the Japanese Orthopaedic Association scoring system between the two groups. However, the PD group showed a higher proportion of non-ambulators and dependent ambulators with walkers at the final follow-up (p < 0.01). Conclusions: A similar surgical strategy can be applicable to patients with PD with OVF in the thoracolumbar junction. However, physicians should pay extra attention to intensive perioperative care to prevent various adverse events and implement a rehabilitation regimen to regain walking ability.

AB - Background: To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of fusion surgery for patients with Parkinson's disease (PD) with osteoporotic vertebral fracture (OVF) in the thoracolumbar junction. Methods: Retrospectively registered data were collected from 27 universities and their affiliated hospitals in Japan. In total, 26 patients with PD (mean age, 76 years; 3 men and 23 women) with thoracolumbar OVF who underwent spinal fusion with a minimum of 2 years of follow-up were included (PD group). Surgical invasion, perioperative complications, radiographic sagittal alignment, mechanical failure (MF) related to instrumentation, and clinical outcomes were evaluated. A control group of 296 non-PD patients (non-PD group) matched for age, sex, distribution of surgical procedures, number of fused segments, and follow-up period were used for comparison. Results: The PD group showed higher rates of perioperative complications (p < 0.01) and frequency of delirium than the non-PD group (p < 0.01). There were no significant differences in the degree of kyphosis correction, frequency of MF, visual analog scale of the symptoms, and improvement according to the Japanese Orthopaedic Association scoring system between the two groups. However, the PD group showed a higher proportion of non-ambulators and dependent ambulators with walkers at the final follow-up (p < 0.01). Conclusions: A similar surgical strategy can be applicable to patients with PD with OVF in the thoracolumbar junction. However, physicians should pay extra attention to intensive perioperative care to prevent various adverse events and implement a rehabilitation regimen to regain walking ability.

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