Surgical resection for lymph node metastasis after liver transplantation for hepatocellular carcinoma

Toru Ikegami, Tomoharu Yoshizumi, Jyunji Kawasaki, Akihisa Nagatsu, Hideaki Uchiyama, Noboru Harada, Norifumi Harimoto, Shinji Itoh, Takashi Motomura, Yuji Soejima, Yoshihiko Maehara

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Abstract

Background: Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. Patients and Methods: The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. Results: The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving nonsurgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence. Conclusion: Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.

Original languageEnglish
Pages (from-to)891-896
Number of pages6
JournalAnticancer research
Volume37
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

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Liver Transplantation
Hepatocellular Carcinoma
Lymph Nodes
Neoplasm Metastasis
Recurrence
Radiation
Drug Therapy
Hepatic Artery
Inferior Vena Cava
Therapeutics
Diaphragm
Stomach

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Surgical resection for lymph node metastasis after liver transplantation for hepatocellular carcinoma. / Ikegami, Toru; Yoshizumi, Tomoharu; Kawasaki, Jyunji; Nagatsu, Akihisa; Uchiyama, Hideaki; Harada, Noboru; Harimoto, Norifumi; Itoh, Shinji; Motomura, Takashi; Soejima, Yuji; Maehara, Yoshihiko.

In: Anticancer research, Vol. 37, No. 2, 01.01.2017, p. 891-896.

Research output: Contribution to journalArticle

Ikegami, Toru ; Yoshizumi, Tomoharu ; Kawasaki, Jyunji ; Nagatsu, Akihisa ; Uchiyama, Hideaki ; Harada, Noboru ; Harimoto, Norifumi ; Itoh, Shinji ; Motomura, Takashi ; Soejima, Yuji ; Maehara, Yoshihiko. / Surgical resection for lymph node metastasis after liver transplantation for hepatocellular carcinoma. In: Anticancer research. 2017 ; Vol. 37, No. 2. pp. 891-896.
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AU - Harada, Noboru

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AU - Soejima, Yuji

AU - Maehara, Yoshihiko

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