Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer

Satoshi Ida, Masaru Morita, Yukiharu Hiyoshi, Keisuke Ikeda, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Tetsuya Kusumoto, Sei Yoshida, Torahiko Nakashima, Masayuki Watanabe, Hideo Baba, Yoshihiko Maehara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.

Original languageEnglish
Pages (from-to)1175-1181
Number of pages7
JournalAnnals of Surgical Oncology
Volume21
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

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Hypopharynx
Esophagectomy
Esophageal Neoplasms
Uterine Cervical Neoplasms
Thorax
Neoplasms
Radiation
Chemoradiotherapy
Jejunum
Stomach
Necrosis
Survival Rate
Transplants

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer. / Ida, Satoshi; Morita, Masaru; Hiyoshi, Yukiharu; Ikeda, Keisuke; Andou, Kouji; Kimura, Yasue; Saeki, Hiroshi; Oki, Eiji; Kusumoto, Tetsuya; Yoshida, Sei; Nakashima, Torahiko; Watanabe, Masayuki; Baba, Hideo; Maehara, Yoshihiko.

In: Annals of Surgical Oncology, Vol. 21, No. 4, 01.01.2014, p. 1175-1181.

Research output: Contribution to journalArticle

Ida, Satoshi ; Morita, Masaru ; Hiyoshi, Yukiharu ; Ikeda, Keisuke ; Andou, Kouji ; Kimura, Yasue ; Saeki, Hiroshi ; Oki, Eiji ; Kusumoto, Tetsuya ; Yoshida, Sei ; Nakashima, Torahiko ; Watanabe, Masayuki ; Baba, Hideo ; Maehara, Yoshihiko. / Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer. In: Annals of Surgical Oncology. 2014 ; Vol. 21, No. 4. pp. 1175-1181.
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T1 - Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer

AU - Ida, Satoshi

AU - Morita, Masaru

AU - Hiyoshi, Yukiharu

AU - Ikeda, Keisuke

AU - Andou, Kouji

AU - Kimura, Yasue

AU - Saeki, Hiroshi

AU - Oki, Eiji

AU - Kusumoto, Tetsuya

AU - Yoshida, Sei

AU - Nakashima, Torahiko

AU - Watanabe, Masayuki

AU - Baba, Hideo

AU - Maehara, Yoshihiko

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.

AB - Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.

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