Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)

Eiji Oki, Shoji Tokunaga, Yasunori Emi, Tetsuya Kusumoto, Manabu Yamamoto, Kengo Fukuzawa, Ikuo Takahashi, Sumiya Ishigami, Akihito Tsuji, Hidefumi Higashi, Toshihiko Nakamura, Hiroshi Saeki, Ken Shirabe, Yoshihiro Kakeji, Kenji Sakai, Hideo Baba, Tadashi Nishimaki, Shoji Natsugoe, Yoshihiko Maehara

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: The necessity of surgical treatment of liver metastases of gastric cancer is still controversial. Patients and methods: We conducted a multicenter retrospective cohort study of liver-limited metastasis of gastric cancer treated surgically between 2000 and 2010. In this study, 103 patients were registered, with nine patients excluded from the analysis as they did not meet the eligibility criteria. Results: Of the 94 patients, 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep tumors, and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 patients, respectively. The 3- and 5-year overall survival rates of all the patients were 51.4 and 42.3 %, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7 %, respectively. No significant difference in prognosis was observed between the patients who underwent surgical resection and those who underwent ablation therapy. The patients with hepatic solitary lesions and low-grade lymph node metastases of primary gastric cancer had significantly better overall survival and relapse-free survival. Conclusions: To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection.

Original languageEnglish
Pages (from-to)968-976
Number of pages9
JournalGastric Cancer
Volume19
Issue number3
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Multicenter Studies
Stomach Neoplasms
Cohort Studies
Neoplasm Metastasis
Liver
Therapeutics
Microwaves
Survival Rate
Lymph Nodes
Recurrence
Survival
Retrospective Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

Surgical treatment of liver metastasis of gastric cancer : a retrospective multicenter cohort study (KSCC1302). / Oki, Eiji; Tokunaga, Shoji; Emi, Yasunori; Kusumoto, Tetsuya; Yamamoto, Manabu; Fukuzawa, Kengo; Takahashi, Ikuo; Ishigami, Sumiya; Tsuji, Akihito; Higashi, Hidefumi; Nakamura, Toshihiko; Saeki, Hiroshi; Shirabe, Ken; Kakeji, Yoshihiro; Sakai, Kenji; Baba, Hideo; Nishimaki, Tadashi; Natsugoe, Shoji; Maehara, Yoshihiko.

In: Gastric Cancer, Vol. 19, No. 3, 01.07.2016, p. 968-976.

Research output: Contribution to journalArticle

Oki, E, Tokunaga, S, Emi, Y, Kusumoto, T, Yamamoto, M, Fukuzawa, K, Takahashi, I, Ishigami, S, Tsuji, A, Higashi, H, Nakamura, T, Saeki, H, Shirabe, K, Kakeji, Y, Sakai, K, Baba, H, Nishimaki, T, Natsugoe, S & Maehara, Y 2016, 'Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)', Gastric Cancer, vol. 19, no. 3, pp. 968-976. https://doi.org/10.1007/s10120-015-0530-z
Oki, Eiji ; Tokunaga, Shoji ; Emi, Yasunori ; Kusumoto, Tetsuya ; Yamamoto, Manabu ; Fukuzawa, Kengo ; Takahashi, Ikuo ; Ishigami, Sumiya ; Tsuji, Akihito ; Higashi, Hidefumi ; Nakamura, Toshihiko ; Saeki, Hiroshi ; Shirabe, Ken ; Kakeji, Yoshihiro ; Sakai, Kenji ; Baba, Hideo ; Nishimaki, Tadashi ; Natsugoe, Shoji ; Maehara, Yoshihiko. / Surgical treatment of liver metastasis of gastric cancer : a retrospective multicenter cohort study (KSCC1302). In: Gastric Cancer. 2016 ; Vol. 19, No. 3. pp. 968-976.
@article{74281cab5ede4073a405f0583df6a9b8,
title = "Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)",
abstract = "Background: The necessity of surgical treatment of liver metastases of gastric cancer is still controversial. Patients and methods: We conducted a multicenter retrospective cohort study of liver-limited metastasis of gastric cancer treated surgically between 2000 and 2010. In this study, 103 patients were registered, with nine patients excluded from the analysis as they did not meet the eligibility criteria. Results: Of the 94 patients, 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep tumors, and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 patients, respectively. The 3- and 5-year overall survival rates of all the patients were 51.4 and 42.3 {\%}, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7 {\%}, respectively. No significant difference in prognosis was observed between the patients who underwent surgical resection and those who underwent ablation therapy. The patients with hepatic solitary lesions and low-grade lymph node metastases of primary gastric cancer had significantly better overall survival and relapse-free survival. Conclusions: To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection.",
author = "Eiji Oki and Shoji Tokunaga and Yasunori Emi and Tetsuya Kusumoto and Manabu Yamamoto and Kengo Fukuzawa and Ikuo Takahashi and Sumiya Ishigami and Akihito Tsuji and Hidefumi Higashi and Toshihiko Nakamura and Hiroshi Saeki and Ken Shirabe and Yoshihiro Kakeji and Kenji Sakai and Hideo Baba and Tadashi Nishimaki and Shoji Natsugoe and Yoshihiko Maehara",
year = "2016",
month = "7",
day = "1",
doi = "10.1007/s10120-015-0530-z",
language = "English",
volume = "19",
pages = "968--976",
journal = "Gastric Cancer",
issn = "1436-3291",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Surgical treatment of liver metastasis of gastric cancer

T2 - a retrospective multicenter cohort study (KSCC1302)

AU - Oki, Eiji

AU - Tokunaga, Shoji

AU - Emi, Yasunori

AU - Kusumoto, Tetsuya

AU - Yamamoto, Manabu

AU - Fukuzawa, Kengo

AU - Takahashi, Ikuo

AU - Ishigami, Sumiya

AU - Tsuji, Akihito

AU - Higashi, Hidefumi

AU - Nakamura, Toshihiko

AU - Saeki, Hiroshi

AU - Shirabe, Ken

AU - Kakeji, Yoshihiro

AU - Sakai, Kenji

AU - Baba, Hideo

AU - Nishimaki, Tadashi

AU - Natsugoe, Shoji

AU - Maehara, Yoshihiko

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: The necessity of surgical treatment of liver metastases of gastric cancer is still controversial. Patients and methods: We conducted a multicenter retrospective cohort study of liver-limited metastasis of gastric cancer treated surgically between 2000 and 2010. In this study, 103 patients were registered, with nine patients excluded from the analysis as they did not meet the eligibility criteria. Results: Of the 94 patients, 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep tumors, and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 patients, respectively. The 3- and 5-year overall survival rates of all the patients were 51.4 and 42.3 %, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7 %, respectively. No significant difference in prognosis was observed between the patients who underwent surgical resection and those who underwent ablation therapy. The patients with hepatic solitary lesions and low-grade lymph node metastases of primary gastric cancer had significantly better overall survival and relapse-free survival. Conclusions: To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection.

AB - Background: The necessity of surgical treatment of liver metastases of gastric cancer is still controversial. Patients and methods: We conducted a multicenter retrospective cohort study of liver-limited metastasis of gastric cancer treated surgically between 2000 and 2010. In this study, 103 patients were registered, with nine patients excluded from the analysis as they did not meet the eligibility criteria. Results: Of the 94 patients, 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep tumors, and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 patients, respectively. The 3- and 5-year overall survival rates of all the patients were 51.4 and 42.3 %, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7 %, respectively. No significant difference in prognosis was observed between the patients who underwent surgical resection and those who underwent ablation therapy. The patients with hepatic solitary lesions and low-grade lymph node metastases of primary gastric cancer had significantly better overall survival and relapse-free survival. Conclusions: To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection.

UR - http://www.scopus.com/inward/record.url?scp=84938903569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938903569&partnerID=8YFLogxK

U2 - 10.1007/s10120-015-0530-z

DO - 10.1007/s10120-015-0530-z

M3 - Article

C2 - 26260876

AN - SCOPUS:84938903569

VL - 19

SP - 968

EP - 976

JO - Gastric Cancer

JF - Gastric Cancer

SN - 1436-3291

IS - 3

ER -