Surgically resected hepatocellular carcinomas in patients with non-alcoholic steatohepatitis

Takashi Maeda, Koji Hashimoto, Yuki Kihara, Toru Ikegami, Teruyoshi Ishida, Shiomi Aimitsu, Megumu Fujiwara

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background/Aims: Surgically resected hepatocellular carcinomas (HCC) in patients with non-alcoholic steatohepatitis (NASH) have rarely been described and the clinicopathological characteristics of HCC and non-cancerous liver tissue are still obscure. Methodology: From 1997 to 2004, 242 patients with HCC underwent hepatic resection at the Hiroshima Red Cross Hospital and Atomic Bomb Survivors' Hospital. Among this group, the diagnosis of NASH was made in 3 patients. Results: All 3 patients with HCC had cirrhosis. The tumor cells contained Mallory bodies and fat. The non-cancerous areas showed nodular regeneration with fatty changes, ballooning degeneration, and mild inflammatory infiltrates, as well as perivenular and perisinusoidal fibrosis. Conclusions: Patients with NASH and cirrhosis may progress to HCC, and careful follow-up based on tumor markers and imaging modalities, is essential to detect resectable HCC in patients with NASH and cirrhosis.

Original languageEnglish
Pages (from-to)1404-1406
Number of pages3
JournalHepato-gastroenterology
Volume55
Issue number85
Publication statusPublished - Jul 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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