Survival of elderly dialysis patients is predicted by both patient and practice characteristics

Celine Foote, Toshiharu Ninomiya, Martin Gallagher, Vlado Perkovic, Alan Cass, Stephen P. McDonald, Meg Jardine

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background. Increasing numbers of elderly patients face decisions about the management of end-stage kidney disease. Improved understanding of contemporary patient and practice factors influencing prognosis may assist decision making for individual patients and their care providers. Methods. This is a prospective registry study using multivariable proportional hazards models.A total of 1781 patients aged <75 years at dialysis initiation recorded in ANZDATA, the Australia and New Zealand renal replacement registry, between January 2002 and December 2005.The patient characteristics were demographic and comorbid conditions. The practice characteristics were late referral, access at dialysis initiation and intended dialysis modality (modality established by 90 days).The study outcome was mortality censored at 31 December 2007 or at recovery of renal function (of at least 30 days), transplantation or loss to follow-up. Results. Median follow-up was 2.3 years (interquartile range 1.13.3 years) during which time, 65% of the patients died. Baseline factors independently associated with mortality were older age [hazard ratio (HR) 1.24 for 5-year increase, 95% confidence interval (CI) 1.131.36], body mass index <18.5 (HR 1.78, 95% CI 1.332.38), number of comorbidities (one comorbidity HR 1.38, 95% CI 1.131.69; two comorbidities HR 1.55, 95% CI 1.271.89; three or more comorbidities HR 1.89, 95% CI 1.552.31), late referral (HR 1.19, 95% CI 1.021.39), peritoneal dialysis as intended modality (HR 1.26, 95% CI 1.081.47) and unprepared access (HR 1.43, 95% CI 1.231.67).The limitations of the study were the observational nature of the analysis, potential selection bias introduced through analysis of a group who actually commenced dialysis and the potential confounding from unmeasured factors or dichotomous reporting of comorbidities. Conclusions. Within the elderly cohort, other patient characteristics have a greater association with mortality than 5-year age increments. Even after consideration of patient characteristics, practice factors have a striking impact on the survival of elderly patients commencing dialysis. In the absence of randomized studies, efforts to enhance the identification and preparation of elderly patients for dialysis may improve outcomes within current settings.

Original languageEnglish
Pages (from-to)3581-3587
Number of pages7
JournalNephrology Dialysis Transplantation
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1 2012
Externally publishedYes

Fingerprint

Dialysis
Confidence Intervals
Survival
Comorbidity
Registries
Mortality
Referral and Consultation
Kidney
Selection Bias
Recovery of Function
Peritoneal Dialysis
New Zealand
Proportional Hazards Models
Chronic Kidney Failure
Observational Studies
Decision Making
Patient Care
Body Mass Index
Transplantation
Demography

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Survival of elderly dialysis patients is predicted by both patient and practice characteristics. / Foote, Celine; Ninomiya, Toshiharu; Gallagher, Martin; Perkovic, Vlado; Cass, Alan; McDonald, Stephen P.; Jardine, Meg.

In: Nephrology Dialysis Transplantation, Vol. 27, No. 9, 01.09.2012, p. 3581-3587.

Research output: Contribution to journalArticle

Foote, Celine ; Ninomiya, Toshiharu ; Gallagher, Martin ; Perkovic, Vlado ; Cass, Alan ; McDonald, Stephen P. ; Jardine, Meg. / Survival of elderly dialysis patients is predicted by both patient and practice characteristics. In: Nephrology Dialysis Transplantation. 2012 ; Vol. 27, No. 9. pp. 3581-3587.
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abstract = "Background. Increasing numbers of elderly patients face decisions about the management of end-stage kidney disease. Improved understanding of contemporary patient and practice factors influencing prognosis may assist decision making for individual patients and their care providers. Methods. This is a prospective registry study using multivariable proportional hazards models.A total of 1781 patients aged <75 years at dialysis initiation recorded in ANZDATA, the Australia and New Zealand renal replacement registry, between January 2002 and December 2005.The patient characteristics were demographic and comorbid conditions. The practice characteristics were late referral, access at dialysis initiation and intended dialysis modality (modality established by 90 days).The study outcome was mortality censored at 31 December 2007 or at recovery of renal function (of at least 30 days), transplantation or loss to follow-up. Results. Median follow-up was 2.3 years (interquartile range 1.13.3 years) during which time, 65{\%} of the patients died. Baseline factors independently associated with mortality were older age [hazard ratio (HR) 1.24 for 5-year increase, 95{\%} confidence interval (CI) 1.131.36], body mass index <18.5 (HR 1.78, 95{\%} CI 1.332.38), number of comorbidities (one comorbidity HR 1.38, 95{\%} CI 1.131.69; two comorbidities HR 1.55, 95{\%} CI 1.271.89; three or more comorbidities HR 1.89, 95{\%} CI 1.552.31), late referral (HR 1.19, 95{\%} CI 1.021.39), peritoneal dialysis as intended modality (HR 1.26, 95{\%} CI 1.081.47) and unprepared access (HR 1.43, 95{\%} CI 1.231.67).The limitations of the study were the observational nature of the analysis, potential selection bias introduced through analysis of a group who actually commenced dialysis and the potential confounding from unmeasured factors or dichotomous reporting of comorbidities. Conclusions. Within the elderly cohort, other patient characteristics have a greater association with mortality than 5-year age increments. Even after consideration of patient characteristics, practice factors have a striking impact on the survival of elderly patients commencing dialysis. In the absence of randomized studies, efforts to enhance the identification and preparation of elderly patients for dialysis may improve outcomes within current settings.",
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AU - Foote, Celine

AU - Ninomiya, Toshiharu

AU - Gallagher, Martin

AU - Perkovic, Vlado

AU - Cass, Alan

AU - McDonald, Stephen P.

AU - Jardine, Meg

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N2 - Background. Increasing numbers of elderly patients face decisions about the management of end-stage kidney disease. Improved understanding of contemporary patient and practice factors influencing prognosis may assist decision making for individual patients and their care providers. Methods. This is a prospective registry study using multivariable proportional hazards models.A total of 1781 patients aged <75 years at dialysis initiation recorded in ANZDATA, the Australia and New Zealand renal replacement registry, between January 2002 and December 2005.The patient characteristics were demographic and comorbid conditions. The practice characteristics were late referral, access at dialysis initiation and intended dialysis modality (modality established by 90 days).The study outcome was mortality censored at 31 December 2007 or at recovery of renal function (of at least 30 days), transplantation or loss to follow-up. Results. Median follow-up was 2.3 years (interquartile range 1.13.3 years) during which time, 65% of the patients died. Baseline factors independently associated with mortality were older age [hazard ratio (HR) 1.24 for 5-year increase, 95% confidence interval (CI) 1.131.36], body mass index <18.5 (HR 1.78, 95% CI 1.332.38), number of comorbidities (one comorbidity HR 1.38, 95% CI 1.131.69; two comorbidities HR 1.55, 95% CI 1.271.89; three or more comorbidities HR 1.89, 95% CI 1.552.31), late referral (HR 1.19, 95% CI 1.021.39), peritoneal dialysis as intended modality (HR 1.26, 95% CI 1.081.47) and unprepared access (HR 1.43, 95% CI 1.231.67).The limitations of the study were the observational nature of the analysis, potential selection bias introduced through analysis of a group who actually commenced dialysis and the potential confounding from unmeasured factors or dichotomous reporting of comorbidities. Conclusions. Within the elderly cohort, other patient characteristics have a greater association with mortality than 5-year age increments. Even after consideration of patient characteristics, practice factors have a striking impact on the survival of elderly patients commencing dialysis. In the absence of randomized studies, efforts to enhance the identification and preparation of elderly patients for dialysis may improve outcomes within current settings.

AB - Background. Increasing numbers of elderly patients face decisions about the management of end-stage kidney disease. Improved understanding of contemporary patient and practice factors influencing prognosis may assist decision making for individual patients and their care providers. Methods. This is a prospective registry study using multivariable proportional hazards models.A total of 1781 patients aged <75 years at dialysis initiation recorded in ANZDATA, the Australia and New Zealand renal replacement registry, between January 2002 and December 2005.The patient characteristics were demographic and comorbid conditions. The practice characteristics were late referral, access at dialysis initiation and intended dialysis modality (modality established by 90 days).The study outcome was mortality censored at 31 December 2007 or at recovery of renal function (of at least 30 days), transplantation or loss to follow-up. Results. Median follow-up was 2.3 years (interquartile range 1.13.3 years) during which time, 65% of the patients died. Baseline factors independently associated with mortality were older age [hazard ratio (HR) 1.24 for 5-year increase, 95% confidence interval (CI) 1.131.36], body mass index <18.5 (HR 1.78, 95% CI 1.332.38), number of comorbidities (one comorbidity HR 1.38, 95% CI 1.131.69; two comorbidities HR 1.55, 95% CI 1.271.89; three or more comorbidities HR 1.89, 95% CI 1.552.31), late referral (HR 1.19, 95% CI 1.021.39), peritoneal dialysis as intended modality (HR 1.26, 95% CI 1.081.47) and unprepared access (HR 1.43, 95% CI 1.231.67).The limitations of the study were the observational nature of the analysis, potential selection bias introduced through analysis of a group who actually commenced dialysis and the potential confounding from unmeasured factors or dichotomous reporting of comorbidities. Conclusions. Within the elderly cohort, other patient characteristics have a greater association with mortality than 5-year age increments. Even after consideration of patient characteristics, practice factors have a striking impact on the survival of elderly patients commencing dialysis. In the absence of randomized studies, efforts to enhance the identification and preparation of elderly patients for dialysis may improve outcomes within current settings.

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