Suzuki coupling for protein modification

Akio Ojida, Hiroshi Tsutsumi, Noriyuki Kasagi, Itaru Hamachi

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Suzuki-coupling, a representative cross-coupling reaction between small molecules, can proceed on a protein surface in aqueous solution under mild conditions. The modified protein produced by the coupling reaction maintained its native like structure and function. In addition, fluorescent dye appended-protein acts as a fluorescent biosensor.

Original languageEnglish
Pages (from-to)3301-3305
Number of pages5
JournalTetrahedron Letters
Issue number19
Publication statusPublished - May 9 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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